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dur-randir | 6 months ago

Shitty shits. Literally. As for metabolic acidoses, rates are extremely low (<10 cases per 100,000 patient-years, per https://pubmed.ncbi.nlm.nih.gov/26773926/), so it's almost a non-concern.

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rscho|6 months ago

~1/10.000 patient-years is a non-concern ?! I hope you're not an epidemiologist.

the__alchemist|6 months ago

I think this depends on the context. For your epidemiologist perspective, or looking at populations, that's a big rate! (Given how much metformin is taken) Would be easy to find people who suffer from it.

From the perspective of "Should I be worried about side effects from taking this drug / should I not take this because it might give me this effect", I think this falls under "be aware of symptoms and stop or weigh the costs if you get it, but you're probably fine".