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New research reveals longevity gains slowing, life expectancy of 100 unlikely

217 points| XzetaU8 | 6 months ago |lafollette.wisc.edu

498 comments

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[+] ggm|6 months ago|reply
Remarkable hostility and strange circular logic from some people posting here. Clearly belief outstrips evidence.

If research suggests there's an observable asymptotic trend, public health dollars at the very least might be better spent on quality of life as much as quantity.

The posts saying an atom of oxygen is potentially infinitely long lived (ignoring radioactive decay?) As a "proof" that life extension has no limit is about as reductively silly as it is possible to be.

Bills of mortality bootstrapped Financial investment in annuities. You think the money people aren't tracking this trend now, when they have for the last 400 or more years?

[+] nabla9|6 months ago|reply
Radical life extension within our lifetimes has become secular religion substitute. It’s driven more by hope and faith than by scientific fact.

While a lifespan has no limits in theory if technology is advanced enough, the belief that it can be achieved by a living person is based on hope rather than evidence.

- Possible in our lifetime.

- Affordable to the faithful.

You remove these two, and the faithful lose their interest in discussing the matter.

[+] inglor_cz|6 months ago|reply
I don't have to be hostile to be somewhat skeptical about mechanical extensions of current trends into distant future.

An analyst living in 1825 could analyze the traffic stats to conclude that the era of increasing land travel speeds is coming to a close because the horses can't run any faster, and an analyst living in 1975 could analyze the telecom stats to conclude that international calls are always going to cost much more than local calls and remain somewhat of a luxury, particularly in the developing world.

In both cases, technological changes intervened.

[+] dfxm12|6 months ago|reply
public health dollars at the very least might be better spent on quality of life as much as quantity.

Improving quality of life often leads to improving quantity of life. Life expectancy is, in part, a policy choice. Be wary of those who are outright against these things.

https://thehill.com/policy/equilibrium-sustainability/570293...

[+] pfdietz|6 months ago|reply
Personal longevity is a topic that seems maximally suited to drive wishful thinking.
[+] StopDisinfo910|6 months ago|reply
> If research suggests there's an observable asymptotic trend, public health dollars at the very least might be better spent on quality of life as much as quantity.

Isn’t that already the case with a ton of research going into cancer treatment, Alzheimer’s treatment and how to keep people healthy longer?

Honestly, having seen the life of my grand parents once they past 90 and especially the last 2 when they had significant dementia, I would much rather die before.

Give me a good life as long as possible and spare me and my family the worst of the decline.

[+] r_singh|6 months ago|reply
The problem is that mistrust is at its highest that it has been. Science and evidence have been used as political tools in the recent past... and it has started becoming clear to more and more people. Either that or to protect financial interests of some legacy chaebol... so people are losing faith.

In my country people both believe and have some evidence that those that live in an orderly fashion, learn to be emotionally detached and focus most of their energies on flow states and forward escapes end up living longer than those who don't and living beyond 100 is not really difficult if one lives a healthy balanced life as prescribed by Yoga philosophy from the get go.

I'm gonna stick my neck out and say that if life's goal is living, like it should be — and not endless economic growth or an endless compulsion on the hedonic treadmill — it isn't hard to live beyond 100.

When life's goal is living every aspect of it from family, to children to rest get the love and attention they deserve and economic outcomes and status games do not dictate life. But for that to happen one needs to realise that the most precious thing they own is their energy and will. And must learn to see which activities increase their leverage and which ones don't. When one lives that way, the most contrarian thing is that you can achieve a lot more than by chasing because you start to intrinsically do rather than chase — the latter being much more expensive energy wise. I understand if this gets too esoteric for HN. But it's what I believe to be true and is also IMHO the reason why many high performing individuals seem to be unaffected by illnesses even at old age because their energy is continuously and exponentially directed in virtuous cycles and not disturbed easily by external happenings. You are energy and can be understood and defined entirely mathematically. Yoga means union with the universe's synchronicity. It originates from Sankhya Philosophy which simply means counting all energy.

[+] dsign|6 months ago|reply
I was walking on the street the other day. It was fine summer, and I saw so many elderly walking outside. All of them were using one type of aid or another; some even had a social worker at their side. As I saw them, I was thinking that my 63% marginal tax was paying for it, while I part with 25% of my income after taxes to pay my mom’s pension. That monetary cost is nothing, I would gladly pay it for the rest of my life if it could give my mom a good life for that long. Her old age is my single biggest source of stress.

In the political sphere, some countries are tearing themselves apart on the question of immigration and identity. But immigration is the only thing that can replenish their workforce.

So, we are paying an extremely high cost for letting God go on with His Slow Tormentous Cooking of Souls before Consumption, and things are only going to get worse, given the demographic expectations. Wouldn’t it make sense to put a big chunk of budget into creating life-extension tech?

[+] joelthelion|6 months ago|reply
> So, we are paying an extremely high cost for letting God go on with His Slow Tormentous Cooking of Souls before Consumption, and things are only going to get worse, given the demographic expectations. Wouldn’t it make sense to put a big chunk of budget into creating life-extension tech?

It's controversial, but I think it would be tremendously beneficial to our society if we accepted that death is (currently) inevitable and that past some point, assisted suicide is a lot better than artificially prolonging suffering at great cost for as long as possible.

[+] simianparrot|6 months ago|reply
> But immigration is the only thing that can replenish their workforce.

Unchecked immigration of people who do not share the majority of the destination’s cultural values leads to a monoculture that is terrible for everyone. Multiculturalism doesn’t work when everyone’s culture is equal everywhere. And unless it wasn’t obvious, I firmly believe in multiculturalism, but I believe we (here in Europe in particular) have been misled about what it should look like. And no it’s not about ethnicity.

And that’s saying nothing about the impact on source countries as some other comments go into.

[+] kruffalon|6 months ago|reply
> But immigration is the only thing that can replenish their workforce.

Not in a sustainable way.

Immigration is only viable as long as the countries of origin are so bad to live in so it's "better" to migrate. This is not really a world we want, is it?

[+] grues-dinner|6 months ago|reply
> Wouldn’t it make sense to put a big chunk of budget into creating life-extension tech?

Only if it can improve life quality rather than length alone.

Of course if we make it so you can live to 200 in the body of a 24-year-old and then suddenly drop dead, the good news is there will be no pensions to pay any more and the bad news is you will drop dead at your 180th year at work.

Which is not to say I would not take that deal. Aging is brutal and I've just about had enough already!

[+] 4gotunameagain|6 months ago|reply
> But immigration is the only thing that can replenish their workforce.

You cannot discount the destabilising potential of immigration, and the lowering of societal trust it comes with. As we saw multiple times, integration is the edge case and not the rule. It will be especially harder to integrate people the way the demographic pyramid is looking right now in "developed" countries.

I would also question the desire of immigrants to pay for the welfare of the senile of their respective state, given the fact that they are more than likely to feel mistreated and wronged by the western, "developed" countries that will be hosting them.

I am an immigrant (expat?). I don't enjoy paying contributions for the welfare of the people who played in a huge role in the reasons I had to emigrate.

[+] carlosjobim|6 months ago|reply
> But immigration is the only thing that can replenish their workforce.

Have you ever asked yourself what the purpose is of what you call "workforce"? Exactly what work are they doing that is more important than the survival of the native population? It's completely dehumanizing, and I can't find the logic behind it. If a geographical place needs constant influx of people from other places because the "system" there is slowly killing the population, then for what purpose should that continue?

[+] lotsofpulp|6 months ago|reply
> As I saw them, I was thinking that my 63% marginal tax was paying for it, while I part with 25% of my income after taxes to pay my mom’s pension. That monetary cost is nothing, I would gladly pay it for the rest of my life if it could give my mom a good life for that long. Her old age is my single biggest source of stress.

That “monetary cost” is not nothing. It represents a share of the finite resources your tribe has (individual/family/city/country) being spent on something with little return for future generations.

Developed countries are asking people who put in the effort to raise kids well to support those that don’t. That works when maybe 1 in 10 people don’t raise kids well, for whatever reason, but it doesn’t work so well when large portions of the population do not.

And there very well may be a justification to not raise kids well, but the math is going to be the math regardless of justifications.

[+] abeppu|6 months ago|reply
I think it's important to distinguish between "life expectancy gains have slowed substantially" vs "meaningful longevity increases are not reachable".

A huge fraction of deaths in the developed world are from "lifestyle diseases" from obesity, poor food choices, sedentary behaviors, alcohol, tobacco, etc, all of which we could improve. We eat too many highly processed foods, added sugars, etc. We have places without infrastructure for clean water. We have gun deaths and traffic deaths, and we have bad gun laws and car-centric communities. We have flooding/hurricane/heatwave deaths and we have a climate-denial public policy. There are _so many fixable things_ that shorten people's lives, and we'd all probably also live happier lives if we fixed them.

[+] irrational|6 months ago|reply
Is it just genetic? On my father’s side, people typically live to 100 at a minimum and are perfectly healthy mentally and physically right up till a week or so before they die. My grandmother is 103 and can still lives alone in her house and can walk unassisted, has a memory sharp as anything, and so on. Maybe look at long lived families and figure out what is different about them?
[+] Swizec|6 months ago|reply
What about quality of life adjusted life years? I don’t want to live to 100 and be miserable for the last 30

But if you can get me 90 years where I feel like a spring chicken until 89, then that’s just fine.

[+] fcatalan|6 months ago|reply
My grandfather lived to 102 and only the last few months were bad, nothing dramatic, just fading away at home, no hospital.

I'd sign up for the same

[+] melling|6 months ago|reply
Yes, the term is “health span” and that’s basically what everyone is talking about every single time you read an article on the subject.
[+] PeterHolzwarth|6 months ago|reply
You may feel differently when you get there. Be careful of present you making decisions about future you.
[+] jumploops|6 months ago|reply
My grandfather had a little saying at each of his birthdays:

88, feeling great!

89, feeling fine

90, less mighty*

91, not yet done!

92, don’t think I’ll hit 102!

He died a couple years later, just a few months after getting my grandmother into an assisted living facility.

*note, I struggle to recall the rhyme for 90, so this one might not be accurate!

[+] iwontberude|6 months ago|reply
I’d rather be alive engulfed in flames than dead.
[+] qgin|6 months ago|reply
New research reveals horse-drawn wagon engineering gains slowing, travel at speeds beyond 12mph unlikely.
[+] ACCount37|6 months ago|reply
Aging isn't even recognized as a disease yet, and it well should be.

Very little research currently goes into attacking aging directly - as opposed to handling things that are in no small part downstream from aging, such as heart disease. A big reason for poor "longevity gains" is lack of trying.

[+] sdeframond|6 months ago|reply
I wonder if I would really like to pour billions of taxpayer money into aging when we are not even able to live a basic healthy lifestyle.

Sleeping well, eating well and exercising does work. Science about this is well-established. So why arent we?

It would not raise the life expectancy to 100 years but it would considerably reduce the health burden on the economy.

[+] Kinrany|6 months ago|reply
Aging itself is not a disease, it's just stuff falling into disrepair over time.

Age-related illnesses shouldn't be dismissed with "they're just old" of course but there's no reason to expect a single cause. Other than passage of time itself.

[+] seanmcdirmid|6 months ago|reply
That’s kind of naive. Plenty of people definitely “try”, billionaires would love to live a few hundred more years. We know how aging occurs, there is degradation in DNA, telomeres shorten, and a bunch of other things. The main problem is that biological life simply can’t undergo overhauls like machines do, and we will probably just solve aging by creating successor beings that can.
[+] imtringued|6 months ago|reply
This would require extreme amounts of embryo selection and getting results will require multiple generations, nothing in your lifetime.

The biggest bottleneck is that humans evolved to have children in their 20s. After that age, the old compete with the young for resources, so there is no evolutionary incentive for humans to live indefinitely.

Aging past fertility is like momentum in stochastic gradient descent.

[+] simianparrot|6 months ago|reply
The assumption that everything can be “fixed” is one I will never understand. It’s so obvious when studying organisms in all their shapes and forms how everything is a tradeoff, and nothing can be stable. The fundamental truth of the universe is change.

Senescence is a tradeoff to ward against cancer earlier in life. Eventually it will lead to cancer as a side effect, but optimally something else has failed before then. You can’t patch it out completely without breaking something else.

[+] userbinator|6 months ago|reply
In other words, 7 bits is still sufficient to hold the age of a human.
[+] ethersteeds|6 months ago|reply
I like my structs packed and my lifetimes finite.
[+] bradley13|6 months ago|reply
Genetics required. Natural evolution has zero interest in old people, so there has been no evolutionary pressure to extend lifespan. Possibly even the opposite.

We could apply that pressure, either through selective breeding over generations, or through direct genetic modification. Maybe we aren't quite there yet, but it won't be long.

Experiments on insects with selective breeding have easily tripled lifespans. How well that would transfer to mammals is hard to say, but a substantial increase is certainly possible.

[+] lemoncookiechip|6 months ago|reply
I find it a tough sell to add another 20 years to life expectancy, considering that by the time you reach 70, most people are already in decline (some worse than others), and the drop from 70 to 80 tends to be steep for many. Those who make it past 80 into their 90s or even 100s often aren’t living particularly fulfilling lives, if you can even call it living at that point.

Losing your vision, your hearing, your mobility, and worst of all, your mind, doesn’t sound very appealing to me.

So unless we find a way to both live longer and to decliner slower, I just don't see the point for the majority of people who will unfortunately live lonely worse lives.

[+] czhu12|6 months ago|reply
I don’t want to be that guy but isn’t this kind of an obvious result? The main claim is that life expectancy improvements in the past century are mostly due to decreases in childhood mortality.

During the Roman period, the average life expectancy was only 22-25 years old because so many babies were dying prematurely.

If you could make it past the age of 10, then you were expected to make it to about 50, which almost doubles life expectancy.

https://en.m.wikipedia.org/wiki/Demography_of_the_Roman_Empi...

[+] somenameforme|6 months ago|reply
There were also major gains in things like access to clean water, general safety from the perils of war (which often drives famines, etc), and so on. If one only looked at e.g. Roman aristocracy (which essentially controls for these sort of variables) then their life expectancy would likely be similar to our own. This exact study was carried out on the Ancient Greeks [1], even prior to the Romans, and found a life expectancy of 72 years. [1]

And while I know some will contest the source, while intentionally conflating the mystical with the historical, even the Bible hits on the average age of man: "The days of our lives are seventy years; And if by reason of strength they are eighty years, Yet their boast is only labor and sorrow; For it is soon cut off, and we fly away."

Notably that is in Psalms, Old Testament, and so it was like written over the time frame of 400-1400BC. And I think it's fairly self evident that that segment was written in the context of plain historical observation with no mysticism implied or stated. Basically life expectancy once you leave childhood, let alone peak longevity, hasn't changed all that much over thousands of years.

[1] - https://pubmed.ncbi.nlm.nih.gov/18359748/

[+] billfor|6 months ago|reply
I think antibiotics also have a lot to do with the initial gains.
[+] echelon|6 months ago|reply
That's 100% on the mark. Infants aren't dying anymore.

Real longevity is hard science and we're still at the punch card phase of biology.

Wake me up when we can make headless, full body monoclonal donors for human head transplants. Antigen free / HLA neutral so immunosuppressants are a thing of the past. That'll cure every cancer except brain and blood, cure every other injury, and increase health span of everything but the brain.

The tough problems:

- religious ick and luddite ick

- artificial gestation

- deactivating the brain stem without impacting development

- keeping the body physiologically active and developmentally normative

- head transplants that preserve spinal cord function

- lots of other ancillary issues with changes to pulmonary and immune flux.

[+] arisAlexis|6 months ago|reply
Humans can't grasp the actual possible future with radical lif extension. They like to be contrarians and talk trash on outlandish science fiction like breakthroughs. It's not everyone's cup to understand the limits of science and usually journalists and old scientists are pretty bad at projecting.
[+] ALittleLight|6 months ago|reply
This looks pretty trivial. Obviously modern gains in life expectancy were from removing things that killed us in early age. This says nothing about future gains in life expectancy which may come from biological/medical interventions that reduce senescence.
[+] ck2|6 months ago|reply
Most longevity supplements and drugs work by pulling biological processes to baseline

That's all they do

So for someone sitting around 24/7 maybe vaguely helpful

For someone active, they defeat stress adaptations, so your "gains" disappear or never happen in the first place

They also do nothing for disease, they may help avoid some disease but once the disease is in progress, they can't cure anything

There's going to have to be a "next gen" of such drugs, years if not decades away

The next-gen will probably deal with mitochondria function, enhancing and restoring/rebooting dysfunction, which actually might cure some disease

So hopefully investment will continue towards "next gen", it's a very long road

[+] dyauspitr|6 months ago|reply
Life extension will happen. It’s really just a matter of time with the upper bound being no later than a century from now in my opinion.
[+] bigmattystyles|6 months ago|reply
I wonder if as a species we can ever get more comfortable with death. We’re built not to be I realize, and we should never be for those that are young but I feel like we should be ok with living 80ish or more years and then clocking out. That being said, I’m not cool with the idea of dying when good, but when I’m in a major depressive episode, the idea of immortality is terrifying.
[+] giantg2|6 months ago|reply
There are plenty of longevity things and new meds still being researched. Living longer is possible and there are a fair number of people who make it to 100 all things considered. However, life expectancy reaching 100 does seem unlikely to me. With the issues of drugs and obesity being rampant in many parts of the population, what can we expect?
[+] tossandthrow|6 months ago|reply
People have been conditioned to think in exponential growth.

Some generations ago that was likely also a reasonable approximation.

But with the hyper growth we see today, it becomes ever clear that we always work with sigmoidal growth.

We can see that because more an more system are in the latter half of the sigmoid.

[+] picafrost|6 months ago|reply
I admire the human belief that the improvement of technology and our living standards will be infinite. It will be a bitter moment if we finally realize the plateau we've been stuck on is not temporary and all future gains will be marginal.