[DavidSJ]

while Alzheimers drugs may be more effective earlier in the disease course, none of them are "effective" in the sense of meaningfully staving the disease off; the upside to early detection is not very strong.

One correction here: the amyloid antibodies that successfully clear out a large amount of plaque have yet to report data from intervention trials prior to symptom onset, so we can’t say this with confidence and in fact we have good reason to suspect they would be more effective at this disease stage.

I wrote about this and related topics here: https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...

Edited to add: the sort of test discussed in the OP wouldn’t be relevant to presymptomatic treatment, however, since it’s a test of symptoms rather than biomarkers for preclinical disease.

[pedalpete]

That is an amazing breakdown of AD, and I think it will be my go-to for sharing in the future.

Have you seen the research in phase-targeted auditory stimulation, memory, amyloid, and sleep? Do you have thoughts on that?

Acoustic stimulation during sleep predicts long-lasting increases in memory performance and beneficial amyloid response in older adults - https://doi.org/10.1093/ageing/afad228

Acoustic Stimulation to Improve Slow-Wave Sleep in Alzheimer's Disease: A Multiple Night At-Home Intervention https://doi.org/10.1016/j.jagp.2024.07.002

[DavidSJ]

Thank you for your kind words.

I hadn’t seen that research, thanks for passing it along. It seems like an interesting approach to improve slow wave sleep, which is known to help with amyloid clearance.