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Does Acetaminophen During Pregnancy Increase Autism Risk? A Look at the Evidence

6 points| uws | 5 months ago |braxfordjournal.com

13 comments

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ben30|5 months ago

The political circus is drowning out some pretty clear science here. Let me break this down without the academic jargon:

The basic problem: Most studies can't tell the difference between the medicine and why you're taking it. If you're having Tylenol during pregnancy, it's probably because you have a fever, infection, or severe pain. Guess what also increases autism risk? Fever, infections, and severe illness.

What makes the Swedish study special: They compared siblings in the same family. Same genes, same environment, same parents - but one child was exposed to acetaminophen in the womb and the other wasn't. This controls for all the family-level stuff that usually confuses these studies.

The numbers tell the story: - Regular studies: "5% increased autism risk with acetaminophen" (HR 1.05) - Swedish sibling comparison: "Actually, no increased risk" (HR 0.98, could be 7% protective to 4% harmful - basically noise) - Meanwhile, untreated fever: 40% increased risk, multiple fevers: 212% increased risk

We have evidence that fever during pregnancy messes with fetal brain development. We have the best study ever done showing acetaminophen doesn't cause autism. So we're going to... stop treating the fever?

It's like refusing to use a fire extinguisher because you're worried it might stain your carpet, while your house burns down.

The Swedish study should have ended this debate. When the science is done correctly, the acetaminophen "risk" vanishes completely.

Sources:

- Swedish study: https://jamanetwork.com/journals/jama/fullarticle/2817406

- Fever-autism evidence: https://molecularautism.biomedcentral.com/articles/10.1186/s...

Ancapistani|5 months ago

> The Swedish study should have ended this debate.

I agree with everything you’ve said except this statement.

I’m of the opinion that a single study should never end debate. It may inform policy, sure, but no end debate. Certainly not unless and until it has been replicated by others.

bvoq|5 months ago

Reasoning from first-principles:

Autism is a neurological disorder where you have more island neurons than long reaching connected neurons.

Vaccines can't cross the blood brain barrier, thereby they can't cause autism. Simply ruled out. Acetaminophen on the other hand is a drug that numbs the brain. It can at least feasibly have an influence.

Next, let's think about painkillers. They numb pain. Pain is linked to far reaching memories and connections. Again, plausible.

Sometimes a crazy man says something true.

potatototoo99|5 months ago

Unfortunately, with Trump politicizing this so much, the waters are very muddy now on any research on this coming from the US. I'll wait for the EU/Japan researchers' review.

maxerickson|5 months ago

How does Trump saying something muddy what scientists and doctors are saying?

Even if he wasn't self serving and incurious, his statements wouldn't be worth more than the actual science.

vixen99|5 months ago

'Evidence That Acetaminophen Triggers Autism in Susceptible Individuals Has Been Ignored and Mishandled for More Than a Decade'

https://www.preprints.org/frontend/manuscript/a6a26b165faf5e...

'Overwhelming evidence shows that exposure of susceptible babies and children to acetaminophen (paracetamol) triggers many if not most cases of autism spectrum disorder, and that oxidative stress causes susceptibility. However, these conclusions have not yet been widely acknowledged or integrated into clinical practice or regulatory guidelines'

IAmBroom|5 months ago

"Not peer-reviewed version"

I too can self-publish anything I want. Would you like to know more about how my kool-aid recipe blocks lizard people brain control?