[karlosvomacka]

What a boatload of crap.

> Statins can be beneficial in patients who have already suffered heart attacks. Cholesterol lowering is not the reason for the benefit of statins. If it was, lowering cholesterol via any means should have produced the same benefit, but it doesn’t.

What a blatant lie! Ppcsk9 inhibitors have produced excellent results, even better than statins.

[timr]

I'm unaware of any evidence for ppcsk9 inhibitors outside of the same cohorts (people with existing CVD) that the OP is citing.

Do you have any?

[breadwinner]

What about Vytorin trial?

Vytorin is a combination of cholesterol-lowering drugs, one called Zetia and the other a statin called Zocor. Because the two drugs lower LDL cholesterol by different mechanisms, the makers of Vytorin (Merck and Schering-Plough) assumed that their double-barreled therapy would lower it more than either drug alone, which it did, and so do a better job of slowing the accumulation of fatty plaques in the arteries - which it did not.

See: https://www.nytimes.com/2008/01/27/opinion/27taubes.html