[DarkmSparks]

Name a single success.

The best treatments on the market slows cognative decline measurements for up to 6 months "maybe" (could just be the result of pain relief), dates back to like 2001, and have nothing to do with amyloids.

>but this did not invalidate the whole research avenue

Indeed, multiple treatments in very expensive human trials based on the research avenue failing to show any kind of measurable clinical efficacy invalidates the research area.

The latest being from just a few days ago

https://www.biospace.com/drug-development/alector-scraps-dem...

[pedalpete]

You're confusing repairing the damage with the cause.

Just because amyloid/tau cause the damage, that doesn't mean removing them repairs.

If rust weakens a structural piece of steel, removing the rust does not repair the integrity of the steel.

[DarkmSparks]

There is exactly zero evidence to show they cause the damage, the only evidence that once existed to say they caused the damage used 100% faked results, which didnt emerge until after the treatments based on it causing the damage failed to show any clinical benefit and stanford launched an investigation into the prof whose students produced the evidence.

They created several treatments that stopped them forming (most prominent being biogens). The result was no difference in cognitive function vs placebo and some 20% of the people who took it suffering from a heamoralgic stroke (which they covered up).

[anon84873628]

There is success every time we understand a new detail about how/why plaques form, how to detect them, and how to remove them. The science is pointing to a world where treating people much earlier in life (before cognitive symptoms actually appear, before tau forms) is going to prevent disease progression for the majority of people and effectively prevent Alzheimer's.