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m_a_g | 3 months ago

> and for good reasons

That prior discussion gives no good reasons. The linked medium posts are, to be frank, trash.

Statins are well-tolerated drugs with little to no noticeable side effects. You might have to try a few. You may need to combine ezetimibe to maintain a moderate statin dosage level, and that's it. (Like the author of this article)

Source: Leading cardiologists worldwide, and doctors of the rich and famous.

discuss

guerby|3 months ago

What the BMJ has to say on this very topic of statins:

https://www.bmj.com/campaign/statins-open-data

So no settled science here.

Unless you consider the BMJ a trash journal of course.

davikr|3 months ago

note: > individuals at low risk of cardiovascular disease

zamadatix|3 months ago

I recently went on a statin (atorvastatin) and found I have the WILDEST dreams of my life if I don't take them in the morning, and my doctor said my liver readings were elevated after use but not enough he wants to switch it yet. Which alternative statins should I be looking at, or do they have even harder side effects to deal with?

matthewdgreen|3 months ago

I have intense anxiety attacks on atorvastatin. Rosuvastatin at the low dose (5mg) doesn’t do much, but at 10mg and 20mg it caused the same effects. It took years and multiple cycles of going on and off the drugs to become confident this was the problem. I switched to Repatha which doesn’t have this problem (it does make me a bit hungry though) but it’s expensive and it took a while for my insurance to approve it.

lateforwork|3 months ago

> Statins are well-tolerated drugs with little to no noticeable side effects.

Sorry, that's nonsense. It is a dangerous drug with plenty of side effects. If it had no side effects it would be sold over the counter. The brain needs cholesterol to function. If you artificially remove cholesterol this is what happens: https://www.health.harvard.edu/cholesterol/new-findings-on-s...

cthalupa|3 months ago

No, your post is nonsense. You link a random article that doesn't even make the argument that you're making - that it's low cholesterol causing the memory loss - or that statins are causing the memory loss at all.

And considering serum cholesterol cannot pass the blood brain barrier and that it is all synthesized de novo in the brain makes it an even sillier claim. Your serum cholesterol level does not have impact on your brain's cholesterol levels.

Quite a few organs have the ability to synthesize cholesterol as needed and can do so just fine. Another area where we make use of cholesterol is for synthesizing hormones... but those organs can all synthesize it de novo just fine too.

The new pkcs9 inhibitors have gotten people down to extremely low levels of LDL (<30 and <10!) and found no impact to cognition, hormone production, etc. We have mendelian randomization studies looking at people that genetically do not produce pkcs9 and have basically nonexistent serum levels of LDL, no impact to cognition, hormone production, etc.

https://pubmed.ncbi.nlm.nih.gov/36779348/

https://www.ahajournals.org/doi/10.1161/ATV.0000000000000164

https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/201...