[swannodette]

Some research on this topic http://edgarmatias.com/papers/hci96/

On OS X you can achieve this with Keyb, Karabiner Elements, etc. It's also easy to do with a programmable keyboard with ZMK/QMK. I've set up my Kinesis 360 Pro this way, being symmetrical means I can access every key easily. Hardware support for sticky keys also helps quite a bit.

[GlumWoodpecker]

Just being pedantic and off-topic here, but macOS hasn't been called OS X for nearly ten years:

https://en.wikipedia.org/wiki/MacOS#macOS

[binaryturtle]

Some of us still use OS X and haven't made the unnecessary switch to any of the macOS that followed it. :)