[wazdra]

Tails works like this, and has gained a lot of traction in the past few years — although one may argue that running from RAM is only indirectly responsible for its popularity.

I think this idea appeals to many people, also concerning remanence: keeping your system and user data separate to the point that you could virtually mount your /home on any given UNIX host, with the added bonus that if the host is not compatible with your setup, you can always reboot it on your USB stick, run a live ISO on RAM, and retrieve a decent work environment.