[aiisjustanif]

> knowledge of what should and shouldn't be, while important, bears no predictive power whatsoever as to what actually ends up happening.

I don’t know if you are intentionally being vague and existential here. However, context matters, and the predictive power is zero sounds unreasonable in the face of history.

I think humans learning that diseases were affecting us and thus leading to solutions like antibiotics and vaccines. It was not guaranteed, but I’m skeptical of the predictive power being zero.