[kipchak]

It could well be the case that the brain can be simulated, but presently we don't know exactly what variables/components must be simulated. Does ongoing neuroplasticity for example need to be a component of simulation? Is there some as of yet unknown causal mechanisms or interactions that may be essential?

[Tadpole9181]

None of those examples cannot be done on pen and paper or otherwise simulated with a different medium, though.

AFAICT, your comment above would need some mechanism that is physically impossible and incalculable to make the argument, and then somehow have that happen in a human brain despite being physically impossible and incalculable.