[Leherenn]

Anecdotally, my gym had a "challenge" some times back where the goal was to achieve the max total volume in one set without pause.

I tried various combos of weight* reps, and in the end the optimum was somewhere in the middle because no matter how light the weight there was a limit for me at about ~150 reps.

In my case, the curve would be: total volume increases quickly initially at you go from max weight/1 rep to something like 20/30 reps, then something of a plateau as things equalise, then it goes down again as you reach the max reps threshold.

[matwood]

Great point. Personally I find lactic acid build up way more limiting for me than muscle fatigue. It's why I gravitated towards power lifting.