[m_a_g]

I’m glad there are this many early adopters. Thanks to them, in 3 to 5 years, all the side effects will be known, including the long-term effects, so I’ll be able to make an informed decision with the support of doctors rather than Claude. I’ll have access to regulated official compounds rather than underground lab compounds that can kill many people with one faulty batch. Please, continue doing what you’re doing, folks!

[cogman10]

> all the side effects will be known

I wish there were some good that came out of this. But these are completely unusable results. It's uncontrolled and not being studied.

Did their testicles fall off because of LLM drug 32, drug 34, drug 2, or a combination of all the drugs they took at the same time? Or maybe it's a combination of their genetic makeup and drug 4.

It'd be like trying to glean any useful medical information from any drug addict. Was the heart attack caused by meth, huffing paint, or one too many cheese burgers? Who knows.

[vibrio]

Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest maybe not. Maybe they remain rare, but as scale and flexibility of use increases, how that may evolve. Hormones are a whole different calculation. With the creative and dosing, combinations, and applications I’m not sure how many from conclusions will be available. I’m not judging good/bad here, I’m just thinking that this “democratization” of medicines (maybe otherwise not available to some) will increase access, with both risks and benefits.

[Roark66]

You know there are regulated labs you can send samples to and serious sellers (like the one I use) attach a testing certificate you can authenticate with the lab. So you know for sure what is it you're getting and what purity etc.

On the actual efficacy and safety fair point. But we're all adults here (I hope). And as for "society's consequences" other people mention most of these compounds are taken is such tiny amounts it is very unlikely they are harmful once they have been out for a couple of years and people have been taking them(for example 250ug every second day for bpc-157 my favourite compound that is proven by research to improve necrotic wound healing in mice and significantly improve injury recovery in my personal experience).

As for modification of hormonal pathways. Retatrutide is in a middle of human trials. There is no indication so far it is harmful. Personally I've not taken it (despite my doc literally pitching ozempic to me a month ago, my bmi is 31 and I never seriously tried to diet in my life - I decided to try "the natural way" first - to be fair the doc was also interested in the improvement in the glucose metabolism not just weight loss in my case). But I might in next 6 months if I don't get the results I want.

[skywhopper]

I’m concerned you are overestimating the value of the certificate of authenticity you’re getting from your supplier. While you may be right that the compounds you intend to take can’t possibly be all that harmful, there’s a good chance what you’re getting may not be what you think, may not be entirely what you think, and likely contains other things that may be harmful, particularly over a longer period of time.