[graboy]

https://www.jacc.org/doi/10.1016/j.jacc.2012.09.017

Across different genetic variants, lower lifetime LDL -> lower risk of death. Check out figure 3.

The causality of LDL -> plaque buildup -> 55-60% [1] of heart disease related deaths is also well understood, so it seems clear to me that preventing plaque buildup in the first place prevents over half of heart disease related deaths.

Would like to know if you disagree, "Minimize LDL at all costs" goes current mainstream medical guidance, so I'd like to disconfirm my beliefs if possible.

[1] Number from deep research.