[suttontom]

I realize this is a nuanced discussion, but could you clarify the predispositions you're referring to? I'm asking because there are people who blame obesity on a predisposition to hunger (obese people have a stronger hunger drive than thin people) but also people who blame it on a predisposition to weight gain, meaning that obese people can eat the same amount of food as thin people and still be obese. Are you saying GLP-1 drugs have refuted the idea of the latter?

[scoofy]

I'm actually saying quite the opposite. That GLP-1 drugs have refuted the idea that people do not have built in biological mechanism that make them obese, whether or not that's on the hunger side (say, ghrelin) or on the amount of stored energy per calorie (say, metabolism, gut microbiome, etc).