[lazarus01]

>> Researchers have pondered what could have caused this sudden turnaround, pointing to the end of the covid-19 pandemic or a rise in drug treatment. A new article, published in Science on January 8th, suggests, instead, that a supply shock drove the decrease.

The supply shock sounds right.

I was volunteering at a state run institution, who had an addiction data science team, at the peak of the opioid crisis. I was developing ml models to predict patient dropout early in a 32 week program. The data and funding for such research was very scarce and it didn't go anywhere.

Treatment for opioid use disorder with medication is highly effective for 50% - 90% who respond well to treatment. The problem with the bottom 50% was early dropout, due to the lack of dissemination of proper treatment protocols and stigma attached to medication for treatment (methadone). I stopped following the work, I became too sensitive, it was pretty depressing.

The pandemic coupled with the increase in illicit fentanyl was just tragic in what it did to people. I remember reading the DEA research, where the precursor for fentanyl came from china and was manufactured and distributed from mexico. Mexico was also manufacturing high quality meth and displaced most of the meth labs in america, coming with increases in meth overdose during the same period. The fentanyl was so cheap compared to traditional heroin manufacturing.

I'm glad the supply seems to have dried up. It was nuts, what was going on a few years ago.

[greygoo222]

The initial spike in overdose deaths were largely caused by government crackdowns on pharma drugs.

[monero-xmr]

You can live with a sustained opioid addiction permanently without major issues. That’s the entire basis of methadone clinics - controlled dispersement of opioids at a level that solves cravings and allows the addict to be functional. It is very sad we don’t allow pharmaceutical grade opioids to be given to addicts in a controlled way, it would eliminate the purity variance that causes overdoses, and prevent the poison mixed in to increase street profits from destroying bodies (tranq, etc)

[cavisne]

Channel 5 did a good piece on "Tranq" which lets China skip the Mexican part of the supply chain as they can mail the finish product straight to the US.

Since the article suggests there must have been a change in china to cause this it seems likely they just moved from fentanyl to tranq.

https://www.youtube.com/watch?v=925wmb-4Yr4&t=1623s&pp=ygUPY...

[_DeadFred_]

Lots of people were getting fent analogs straight from China. Which had me wondering. The guys that I knew that ordered/distributed it (ex-marines that had pill addictions after Iraq/Afghanistan) would get different analogs randomly I guess, and would test each batch on themselves. Some were way more sketchy than others, and they ultimate caught a case with a body from a new batch. Could the less deaths be because of the analogs in production at the time?

[20after4]

I think that many methadone clinics are operating very unethically, to the point I would call it fraudulent. Certainly it's cruel to the patients. They essentially set up the patient to be a lifetime methadone addict. This may be an improvement over getting your fix on the street but it's still addiction dependence and it's expensive (profitable!). I'm unsure if it's just a few or a large fraction of them that operate this way. Maybe my data point is a unique outlier but here's what I saw:

I had a friend who was going through the program in Springfield Missouri, approximately 10 years ago, and the clinic literally increased his dose every week or two. They also had strict controls to make sure the patients actually take the full dose (because otherwise they might sell some of it on the street). So they were left with just 2 options, either drop out of the program and find their fix elsewhere, or accept a gradually increasing dose of methadone, forever. It's a sick program that is set up to make sure patients gradually descend deeper into addiction while they rake in huge profits. It's not really any different from what the drug dealers on the street are doing except that it's even more exploitative and dishonest. The doctors had zero plan for weaning people off of the methadone and some people had been on the program for years, with correspondingly huge doses doled out to them every time they came in. This was 10 years ago, at the time it cost something like $50 per visit, paid by the patient or possibly medicaid.

Edited slightly for clarity.

[deepsun]

Well, addiction or not, the main question is what medics call "quality of life" -- whether a patient can life their life to the full potential.

There are millions of people addicted to caffeine, the most popular psychoactive substance in the world, but as it usually doesn't prevent them to live their life and "be a productive member of society", no one cares of treating caffeine addiction, save for religious societies.

My point is -- is methadone addiction "better" than fentanyl in that regard? If yes, than that's ok.

[SkyPuncher]

Your argument seems to be missing the fact that methadone clinics are serving people with an existing addiction. They didn’t create that addiction, but they can fill the desire created by that addiction in a safe manner.

The ideal situation is the client leverages methadone into a recovery/remission from addiction - but that can be incredibly hard for them to do.

[AndrewKemendo]

Even still today there is no reliable place to source black tar or China White or any of the traditional opium derivatives without having a fentanyl cut.

[t-3]

Isn't this more because the supply of poppy was cut off when the US pulled out of Afghanistan? Users want the good stuff, dealers buy the cheap and available stuff and pretend it's real.