I don't know that there's a consensus on what the limit really is. Semaglutide is good for about 15%, tirzepatide about 20%, and retatrutide about 25%. Some people don't get that much, some people get a lot more. Personally, tirzepatide got me just over 35%. I never got anywhere near max dose, either, I am what is colloquially referred to as a super responder.
Super responders unite, I'm down 32% and shooting for 36% before I hit maintenance. I only made it about half way up the dosage chart before I had to back off due to losing too rapidly (!!). I took a 3 month maintenance and am back to losing again, it's been life changing.
The other wild thing is general health improvement - all of my bloodwork has gone from questionable to better than standard - closer to ideal values than I would ever expect. Liver values, cholesterol, lipids, blood pressure, everything. I expected them to improve but not to the degree that they have, my LDL has gone down by 60%. Actuarial tables say it's given me another ~10 years of probable lifespan, and even more if you think in healthspan.
As you lose weight, your body needs fewer calories to run. That “needed amount” keeps dropping with your size, until it eventually equals what you’re eating on the medication. At that point you’re no longer in a deficit, so weight loss slows or stops.
That is true but requires some extra assumptions to explain why people don't keep losing weight - because the strongest influence on most people's appetite in the short run is how much of a deficit or surplus they're currently in. Thus as TDEE drops, so does hunger.
In "setpoint theory" there's an additional hunger drive based on whether you are below or above a given level of adiposity - your "setpoint". This is often given as an explanation for why people can't keep weight off, and is the sort of thing you'd need to posit to explain why people on GLP-1 inhibitors can't as easily get to lower levels of adiposity.
rootusrootus|1 month ago
jaggederest|1 month ago
The other wild thing is general health improvement - all of my bloodwork has gone from questionable to better than standard - closer to ideal values than I would ever expect. Liver values, cholesterol, lipids, blood pressure, everything. I expected them to improve but not to the degree that they have, my LDL has gone down by 60%. Actuarial tables say it's given me another ~10 years of probable lifespan, and even more if you think in healthspan.
vladgur|1 month ago
1) How is your energy/stamina following the 35% loss
2) Have you done any dexascans/bodyspecs to measure your lean mass percentage before and after your loss
3) Did you take any steps to reduce the muscle loss?
4) with 35% loss, what BMI are you at?
hsuduebc2|1 month ago
doubleunplussed|1 month ago
In "setpoint theory" there's an additional hunger drive based on whether you are below or above a given level of adiposity - your "setpoint". This is often given as an explanation for why people can't keep weight off, and is the sort of thing you'd need to posit to explain why people on GLP-1 inhibitors can't as easily get to lower levels of adiposity.