[exmadscientist]

None at all, if you're setting them up correctly. 100-150 nits (cd/m²) is just about right. I color-calibrate my monitors and this is one step in the flow. I calibrate to 120 nits and find that it's consistently about 33% brightness. Calibrating this way, I can look at a full white screen (think "blank notepad window") with no particular eyestrain.

[cosmic_cheese]

My issue with running most monitors this dim is that colors look so much worse and contrast is lost. It’s not as much of a problem on my OLED phone though, which does tend toward the dimmer side. My desktop monitors (IPS) on the other hand are rarely below 50%.

[exmadscientist]

I have never noticed that problem. But I always adjust brightness as part of a full color calibration, with ICC profile and everything, which probably makes a difference.

I will say that it took a bit to adjust to the first time I did it, but now it's painful to use any monitor at "full" 200+ nit brightness.