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gnramires | 1 month ago
If folding@home helps to understand and model this behavior of molecules (which I guess tends to be difficult and unreliable to do without the aid of computers), it is extremely helpful. Now I don't know other details like, perhaps molecular biology is the bottleneck and there is scant available molecules to analyze (reducing its impact/marginal sensitivity), or perhaps compute really is a bottleneck in this particular problem. But nonetheless it seems like a great project for which contributions do make a difference.
(Note: although, that said, if you were expecting something like 'compute->miracle drug comes out', I believe that's not quite how it works; research in general rarely works that way, I think because the constraint space and problem space that would require this approach is too large and complicated; and in fact I believe many if not most significant discoveries have resulted from playing around and investigating random molecules, often from (nonhuman) animals, plants and bacteria[1]; although molecular sciences (molecular biology) seem to enable a slightly more methodological approach)
[1] The GLP-1 based weight loss drugs for example came from investigating the Gila monster lizard venom https://en.wikipedia.org/wiki/GLP-1_receptor_agonist#History
Bratmon|1 month ago
lloydatkinson|1 month ago