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joel_liu | 1 month ago

Thanks for sharing this timestamp - Levin's retrospective on bioelectricity research is compelling. What fascinates me most is how his work challenges the gene-centric view of development. The experiments showing bioelectric patterns can override genetic instructions (like inducing eye formation in non-eye tissue) reveal a whole layer of morphogenetic information we're just beginning to understand.

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nandomrumber|1 month ago

I don’t believe genetics ever claimed to provide a theory of why eyes grow where eyes grow.

The cells in your eyes have exactly the same DNA as the cells in your big toe, so developmental morphology cannot be explained with DNA alone.

mojosam|29 days ago

> I don’t believe genetics ever claimed to provide a theory of why eyes grow where eyes grow.

That’s the whole point of developmental biology, to show how features of the human body form and develop based on gene expression, the timing of which during embryonic and fetal development itself is dictated by your genes.

If not your genes, what else would determine why you have eyes in about the same place in your head as every other human?

> The cells in your eyes have exactly the same DNA as the cells in your big toe, so developmental morphology cannot be explained with DNA alone.

Sure it can, because while every cell has essentially the same DNA, the expression of genes differs between cells, which is what causes cells to differentiate. And this differentiation also controls development; look up the Hox genes as an example.

RaftPeople|29 days ago

> The cells in your eyes have exactly the same DNA as the cells in your big toe

Is that true?

I know that cells in the brain have significant variability in DNA, but not really aware of what non-neuronal and non-brain cells in general typically have.