I've been on Mounjaro for 4 months now. You normally start with an initial lower dose and increase the dose after a month. I lost 5 kg (~11 lbs) on the initial dose in the first month, and when I increased the dose, I also stopped smoking.
I've been smoking on and off for 20 years. I have stopped (and relapsed) many times, so I believe I can compare. This was a lot easier. I mean, I had cravings, but they weren't really that bad, and while the first week is generally the difficult part, I only had a couple of days with issues. I did not lose weight that month, though, which is fine as I would normally gain a lot due to compensating for cravings.
I increased the dose again and started losing weight. I guess some people gain weight when they stop using GLP-1. Even if that happens, I'm fine with stopping smoking without weight gain.
That's incredible! Smoking is the hardest one of them. Mainly because smokers tend to be skinny, as cigs kill your appetite (unlike alcoholics who tend to be fat) and all GLP-1 effects go together with the weight loss.
Congrats. Smoking is a bitch of a habit and extremely hard to quit.
I was a daily drinker for many years. A "1 or 2 cocktails in the evening" type of person. (And of course, 1 cocktail often meant 2 shots, so 2 cocktails = 4 shots a night.. looking back... yikes)
I started a GLP-1 in February of 2025. Lost a bunch of weight, etc.
What I wasn't expecting was that I'd have such an easy time dropping the daily drinking habit. I'm not convinced GLP's will help if you're truly addicted to alcohol to the point where you need AA and structured programs to break free. But I do think GLP's have the potential to give you the initial "kick" you need to drop the habit if you're otherwise motivated to.
In the first few months of starting the GLP-1, I remember losing enjoyment for eating (and drinking) a lot of things, especially unhealthy stuff (unhealthy foods/drinks tend to not combine well with GLP's). The taste of a cocktail wasn't as appetizing or appealing as it used to be, hard to explain.
This was also my experience. I was a daily drinker, but once I started on tirzepatide I lost all interest. Even after I stopped taking the medicine, I still wasn't interested. I'll occasionally have a cocktail or glass of wine, but it's now a once-a-month sort of thing.
There is a point you made here "losing enjoyment for eating (and drinking)" that I think is The Key, but also not what people think when they hear it without experiencing it. Someone hearing that line might think it makes food "unenjoyable," as in "bad." That is not the case. It is "unenjoyable" as in "lacking in a joyful experience."
After talking with friends of mine who are similarly aged to me but have not had the major weight struggles I've had, I realized one of the biggest differences between us is not our drive or discipline (they envy me in many of these areas), it's in the sheer level of enjoyment that I get out of food and drink that they do not.
There are certain foods that, if I have them, they make me more hungry. I can't physically fit enough spaghetti or chocolate pudding into my mouth to satisfy my craving for it. My favorite beer feels glorious all the way down my throat and into my stomach; I can go from depressed to happy in 10 seconds just from that first gulp. And it's just those specific things. I'm not going to scarf down hard on lasagna or chocolate ice cream. While I enjoy whiskey, wine, cocktails, and other beers, I can have one in a night and be done.
There are also foods that are the opposite. I physically cannot stomach muscles or cuccumber. Putting cauliflower--in any form--on my plate is likely to start an argument. All leafy greens feel like a punishment; I can choke them down, unlike muscles, but I'm not going to like the person who made me do it.
But my friends without weight issues have never had these experiences with any foods. Food is just a way to avoid hunger. Booze is just a way to get drunk. There's no strong emotional connection to any of it.
And GLP-1 agonists completely remove that. I've heard it called "The Food Noise." It's basically a re-baselining of my relationship to food back to what should be "normal." Nothing has a feedback loop of pushing me to consume more anymore. Nothing gives me such strong revulsion that I can't eat it anymore. It's just food, on my plate. I don't even feel hungry, the only reason I'm eating it is because I understand at an intellectual level that I have to in order to not pass out in the middle of the day.
Similar experience. Went through a phase of drinking once or twice a week. Started GLP-1, completely dropped the drinking habit to the point where there is zero desire of drinking.
Now, I wish it could do this for late night sugary snacks as well since that's my crux.
I have heard a few very different experiences with GLP-1s, for some an almost magical relief from addictive behaviors, for others they didn't notice much on that front at all.
I'm surprised that this article doesn't appear to mention the RCT on semaglutide and alcohol use disorder by Hendershot et al. that was published in JAMA Psychiatry in early 2025 (though it's possible I missed it) https://doi.org/10.1001/jamapsychiatry.2024.4789
This was largely portrayed as a great result in the popular press although personally I think it was a bit of a disappointment given all the amazing anecdotes https://dynomight.net/glp-1/
What made it a disappointment? Over only 9 weeks, which is a very short time for habit changes to take hold, there were measurable, statistically significant effects. And at the highest dose was just 1mg / week for one single week at the end, where the maintenance mode for many is 2.4mg / week.
Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.
It's mostly appetite suppressing. Affects the perception of hunger and the brain/reward function of eating, which must also be part of what also helps for drug and alcohol addiction.
It IME doesn't act like an anti-depressant/SSRI which can affect your enthusiasm/desire for your job.
But what if this self-described obsession translates into burnout? Does it actually make you good or just work more compared to your peers? Can you maintain it for the rest of your career?
(I'm just concerned; I've seen many people good at and super into their job end up with burnout, often multiple times because they keep thinking "I used to be good at this!", "I enjoy this!", etc instead of accepting that it was never sustainable in the first place. I suspect people's nervous systems etc are more resilient in their 20's, which is why most people with burnout only start to run into it in their 30's)
Another N=1, I've noticed zero impact on my desire to engage in my normal obsessions while on GLP-1.
What GLP-1 did (initially) was give me horrible insomnia that peaked a couple of days after taking the injection so I had to time my dosage so that I suffered through that on the weekend. That got better over time and eventually went away after about 6 weeks.
Regardless, as another poster mentioned, it's a weekly injection and if you don't like the effects you can stop taking it.
I was excited about effects like this and think they’re entirely absent unless you’re obsessed with food-related app development or something else related to appetite.
> I’d already understood addiction to be a treatable disease, not a personal failing. Still, these scans helped me appreciate how deeply addiction is rooted in neurobiology. A mere photograph of alcohol—to say nothing of a sip—was enough to send a person’s reward centers into a frenzy.
Ban alcohol advertising now and I’m not kidding or being hyperbolic.
Something that has been hinted but not explicitly said: are these drugs performance enhancers? Like the same way you would take Ritalin you'd take these to curb your time wasting habits?
When the research comes in, I will be surprised if they are a performance enhancer outside the health benefits.
Meaning, it is performance-degrading to be overweight. When you remove that? you sleep better you breathe better you move better and therefore think better.
If they are directly performance enhancing, it is in an extremely subtle way- far less than a soda’s worth of caffeine.
Dropping alot of weight rapidly can lead to gallbladder issues. If you're on a GLP-1 please look into this and ask your GP about potentially putting you on Urusodiol.
I saw a thread on reddit where a GP chimed in and mentioned that he was giving urusodiol to all his patients at the same time as GLPs, to help prevent the associated issues.
Either way, modern science is great. Just do your research.
It does seem like a lot of doctors prescribe GLP-1s without any corresponding education on the dietary changes one should make while on them. A friend of mine's mother was hospitalized briefly because she was basically starving herself of proper nutrition while on GLP-1s.
Since I already knew that rapid weight loss is very unhealthy, I intentionally eat very nutrient dense foods in order to keep my weight loss in a reasonable range.
I had an experience similar to the article. Over 18 months, I lost about 85 lbs on Ozempic and Retatrutide. I went from struggling to walk past beer at the at the supermarket - giving in about 50% of the time - to having almost no desire to drink. I only one or two beers every few months. I haven't had a drink alone in two years, and my total alcohol consumption in that entire two year period is less than what I used to drink in a single week.
During this same period, I left an abusive marriage and started exercising extensively. While the causes are complex, I attribute the loss of desire to drink primarily to the GLP-1. Subjectively, I now see drinking as a distraction from programming and other things I enjoy. This feels like my early 20s, when I saw getting drunk as a waste of time, rather than later years when I pushed for another round.
I believe all the stories here about how these drugs helped with their addiction. However I will say I have not experienced this with food addiction which is interesting. I definitely eat less, but when I am hungry I'm still just as likely to eat peanut butter cups or french fries.
Seeing all these articles and studies touting GLP-1s as a magic additive to enhance health and well-being has me so skeptical that there haven't been any major downsides found yet. I guess long-term studies are necessary in order to really understand what we're getting on here.
I would love for it to be miracle it appears to be, since I hate trying to maintain my desired weight. I don't qualify for GLP-1 due to my BMI being too low, but I sure would like to stop the constant cravings for food and my love of beer. Everyday feels like a struggle to maintain a healthy lifestyle.
GLP-1s are the greatest medical innovation of the past decade. Top three, at least, mRNA might give them a run for their money.
There are known side effects, mostly gastrointestinal issues, and they don't work for everyone. That being said, I'd recommend you make your own risk assessment and consider getting on GLP-1s if you have the cash to spare. You might find that GLP-1s increase your quality of life so much that it's well-worth it (or that you get terrible nausea and immediately quit, and then you no longer need to wonder).
Potential risks have to be weighed against potential benefits. There are robust RCT results showing GLP-1s reduce all-cause mortality, major cardiovascular events, and stroke among patients with obesity or T2D by 13-14%, and suggestive evidence that some of these benefits apply to non-overweight people, though this hasn't been confirmed in RCTs and is likely smaller in magnitude.
"Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials": https://www.sciencedirect.com/science/article/pii/S266666772...
One reason to believe that cardiovascular benefits might apply to non-overweight people is that among the available evidence on overweight and obese people, weight loss doesn't seem to explain all benefits. See Figure 1 or the analysis section of the SELECT trial.
The main plausible long-term risk is thyroid cancer. Data from a meta-analysis of RCTs suggests a 55% (large error bars) increase in thyroid cancer risk.
This is concerning, though it's worth noting that thyroid cancer is rare (1% lifetime incidence) and unlikely to kill you (98% 5-year survival, 99.9% when caught early). No studies have linked GLP-1s to a statistically significant increase in cancer-related mortality. I don't want to be too confident because RCTs have not yet shown this and I'm not an Eli Lilly shill, but cohort studies suggest GLP-1s are associated with reduced risk of other cancers. This is a good overview:
It’s not the cure. It’s temporary suppression. I re-sold few times monthly dose of Mounjaro and the buyers catapulted to same bad habits in no time when the last dose stopped working.
Like any medicine, it's something that is intended to be prescribed by doctors to be used under supervision, rather than just taken by people ad-hoc at a random dosage hoping for a miracle.
And as for cure rather than suppression - yes, according to that definition, no medicine that is intended to be taken indefinitely to manage a condition is a cure. But nevertheless, high blood pressure medicine, statins, anti-inflamatories, HIV antiretroviral therapy, and many other drugs have saved many millions of people from an early death. We should keep looking for one-off "cures" for all conditions, but let's not limit ourselves to them.
Same here when I start/stop Mounjaro except I continue to enjoy exercise. Though I'm probably just kidding myself that the exercise is undoing the naughty food
The only way I found to reduce cravings is to be a hermit because there is food absolutely everywhere all the time
This is why on paper nobody is prescribed these drugs until they have followed a program to change lifestyle things like diet. You mention "re-selling Mounjaro" - which implies they just took the drugs without the programs, is that correct? Did you expect anything else?
But for many it's considered a shortcut and there's a big network of dubious online shops and weight loss clinics that sell it. It's not unlike crash / fad diets in that regard.
Most people would already benefit from lifestyle adjustments, but those are hard to do for most people - for starters, most people don't even have regular eating habits to begin with, no baseline to even make adjustments to.
Temporary suppression is a great way to learn how to regulate yourself though.
I quite smoking with cytisine, a drug that basically makes nicotine useless by taking it's place. The pitch is that it's just easier to quite cytisine than nicotine, because unlike nicotine it leaves your system easily.
Wouldn't the same principle work with Mounjaro? Ease off the drug evenly, so you would wouldn't have to overcome big bad addiction all at once, instead you face just a bit of addiction one at the time.
Smoking addiction is way harder to cope that alcohol, only surpassed by opioid. In any case a rigorous study must be performed as nowadays media hype articles about GLP1 drugs mention decline of supermarkets and increased profits by airlines because a few people lost 5-10kgs.
Every time these come up on HN everyone is willing to share their positive anecdote. What are the negative experiences that come with GLP-1s beyond relapse after stopping? I need both sides before I'd consider encouraging anyone to try it.
Rapid muscles loss, unless you are careful and managing it. In my case muscle loss led to increase, not decrease, of the lower back pain related to the crack in one of the vertebrae there. I believe that loss of core muscles increased load on the spine and caused pain. Once I started doing core exercises and cut down on dosage, pain returned back to pre glp1
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
I've found some basic lifestyle changes to be way more effective at weight-loss and inducing well-being than a drastic chemical therapy like Ozempic. Imbibe at your own risk.
- Intermittent fasting (16x8 or at least stop eating after sun down)
- Daily morning pranayama (or 'breath work' if you prefer that term)
- Daily morning intake of copper utensil stored water (~8 hours or overnight)
- Weekly oil pulling for gum health.
This approach feels a bit stoic and neanderthal initially, less attuned to our modern and progressive society, but as effective as Ozempic in long-run (minus the side-effects or addiction).
eknkc|21 days ago
I've been smoking on and off for 20 years. I have stopped (and relapsed) many times, so I believe I can compare. This was a lot easier. I mean, I had cravings, but they weren't really that bad, and while the first week is generally the difficult part, I only had a couple of days with issues. I did not lose weight that month, though, which is fine as I would normally gain a lot due to compensating for cravings.
I increased the dose again and started losing weight. I guess some people gain weight when they stop using GLP-1. Even if that happens, I'm fine with stopping smoking without weight gain.
anovikov|21 days ago
Congrats. Smoking is a bitch of a habit and extremely hard to quit.
cj|21 days ago
I started a GLP-1 in February of 2025. Lost a bunch of weight, etc.
What I wasn't expecting was that I'd have such an easy time dropping the daily drinking habit. I'm not convinced GLP's will help if you're truly addicted to alcohol to the point where you need AA and structured programs to break free. But I do think GLP's have the potential to give you the initial "kick" you need to drop the habit if you're otherwise motivated to.
In the first few months of starting the GLP-1, I remember losing enjoyment for eating (and drinking) a lot of things, especially unhealthy stuff (unhealthy foods/drinks tend to not combine well with GLP's). The taste of a cocktail wasn't as appetizing or appealing as it used to be, hard to explain.
I'd love to see more research around this.
glp1guide|21 days ago
Looks like we posted around the same time, but see:
https://news.ycombinator.com/item?id=46945756
nkohari|21 days ago
moron4hire|20 days ago
There is a point you made here "losing enjoyment for eating (and drinking)" that I think is The Key, but also not what people think when they hear it without experiencing it. Someone hearing that line might think it makes food "unenjoyable," as in "bad." That is not the case. It is "unenjoyable" as in "lacking in a joyful experience."
After talking with friends of mine who are similarly aged to me but have not had the major weight struggles I've had, I realized one of the biggest differences between us is not our drive or discipline (they envy me in many of these areas), it's in the sheer level of enjoyment that I get out of food and drink that they do not.
There are certain foods that, if I have them, they make me more hungry. I can't physically fit enough spaghetti or chocolate pudding into my mouth to satisfy my craving for it. My favorite beer feels glorious all the way down my throat and into my stomach; I can go from depressed to happy in 10 seconds just from that first gulp. And it's just those specific things. I'm not going to scarf down hard on lasagna or chocolate ice cream. While I enjoy whiskey, wine, cocktails, and other beers, I can have one in a night and be done.
There are also foods that are the opposite. I physically cannot stomach muscles or cuccumber. Putting cauliflower--in any form--on my plate is likely to start an argument. All leafy greens feel like a punishment; I can choke them down, unlike muscles, but I'm not going to like the person who made me do it.
But my friends without weight issues have never had these experiences with any foods. Food is just a way to avoid hunger. Booze is just a way to get drunk. There's no strong emotional connection to any of it.
And GLP-1 agonists completely remove that. I've heard it called "The Food Noise." It's basically a re-baselining of my relationship to food back to what should be "normal." Nothing has a feedback loop of pushing me to consume more anymore. Nothing gives me such strong revulsion that I can't eat it anymore. It's just food, on my plate. I don't even feel hungry, the only reason I'm eating it is because I understand at an intellectual level that I have to in order to not pass out in the middle of the day.
nkotov|20 days ago
Now, I wish it could do this for late night sugary snacks as well since that's my crux.
colechristensen|21 days ago
dynm|21 days ago
This was largely portrayed as a great result in the popular press although personally I think it was a bit of a disappointment given all the amazing anecdotes https://dynomight.net/glp-1/
llm_nerd|21 days ago
Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.
xdkyx|21 days ago
rat9988|21 days ago
coredog64|21 days ago
kerbs|21 days ago
It IME doesn't act like an anti-depressant/SSRI which can affect your enthusiasm/desire for your job.
Absolutely life changing drug for me.
Cthulhu_|21 days ago
(I'm just concerned; I've seen many people good at and super into their job end up with burnout, often multiple times because they keep thinking "I used to be good at this!", "I enjoy this!", etc instead of accepting that it was never sustainable in the first place. I suspect people's nervous systems etc are more resilient in their 20's, which is why most people with burnout only start to run into it in their 30's)
ainch|21 days ago
alyandon|21 days ago
What GLP-1 did (initially) was give me horrible insomnia that peaked a couple of days after taking the injection so I had to time my dosage so that I suffered through that on the weekend. That got better over time and eventually went away after about 6 weeks.
Regardless, as another poster mentioned, it's a weekly injection and if you don't like the effects you can stop taking it.
awakeasleep|21 days ago
graboy|21 days ago
marstall|21 days ago
46493168|20 days ago
> I’d already understood addiction to be a treatable disease, not a personal failing. Still, these scans helped me appreciate how deeply addiction is rooted in neurobiology. A mere photograph of alcohol—to say nothing of a sip—was enough to send a person’s reward centers into a frenzy.
Ban alcohol advertising now and I’m not kidding or being hyperbolic.
xnx|7 days ago
Agree. Don't need to make it illegal. Free speech doesn't mean the right to say anything to anyone at anytime.
geremiiah|21 days ago
awakeasleep|21 days ago
Meaning, it is performance-degrading to be overweight. When you remove that? you sleep better you breathe better you move better and therefore think better.
If they are directly performance enhancing, it is in an extremely subtle way- far less than a soda’s worth of caffeine.
unknown|21 days ago
[deleted]
jaboutboul|21 days ago
I saw a thread on reddit where a GP chimed in and mentioned that he was giving urusodiol to all his patients at the same time as GLPs, to help prevent the associated issues.
Either way, modern science is great. Just do your research.
alyandon|20 days ago
Since I already knew that rapid weight loss is very unhealthy, I intentionally eat very nutrient dense foods in order to keep my weight loss in a reasonable range.
dawnerd|21 days ago
ltbarcly3|21 days ago
During this same period, I left an abusive marriage and started exercising extensively. While the causes are complex, I attribute the loss of desire to drink primarily to the GLP-1. Subjectively, I now see drinking as a distraction from programming and other things I enjoy. This feels like my early 20s, when I saw getting drunk as a waste of time, rather than later years when I pushed for another round.
eagsalazar2|20 days ago
joncrane|20 days ago
baggachipz|20 days ago
I would love for it to be miracle it appears to be, since I hate trying to maintain my desired weight. I don't qualify for GLP-1 due to my BMI being too low, but I sure would like to stop the constant cravings for food and my love of beer. Everyday feels like a struggle to maintain a healthy lifestyle.
greygoo222|20 days ago
There are known side effects, mostly gastrointestinal issues, and they don't work for everyone. That being said, I'd recommend you make your own risk assessment and consider getting on GLP-1s if you have the cash to spare. You might find that GLP-1s increase your quality of life so much that it's well-worth it (or that you get terrible nausea and immediately quit, and then you no longer need to wonder).
Potential risks have to be weighed against potential benefits. There are robust RCT results showing GLP-1s reduce all-cause mortality, major cardiovascular events, and stroke among patients with obesity or T2D by 13-14%, and suggestive evidence that some of these benefits apply to non-overweight people, though this hasn't been confirmed in RCTs and is likely smaller in magnitude.
"Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials": https://www.sciencedirect.com/science/article/pii/S266666772...
One reason to believe that cardiovascular benefits might apply to non-overweight people is that among the available evidence on overweight and obese people, weight loss doesn't seem to explain all benefits. See Figure 1 or the analysis section of the SELECT trial.
"Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial": https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
The main plausible long-term risk is thyroid cancer. Data from a meta-analysis of RCTs suggests a 55% (large error bars) increase in thyroid cancer risk.
"GLP-1 receptor agonists and the risk for cancer: A meta-analysis of randomized controlled trials": https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/do...
This is concerning, though it's worth noting that thyroid cancer is rare (1% lifetime incidence) and unlikely to kill you (98% 5-year survival, 99.9% when caught early). No studies have linked GLP-1s to a statistically significant increase in cancer-related mortality. I don't want to be too confident because RCTs have not yet shown this and I'm not an Eli Lilly shill, but cohort studies suggest GLP-1s are associated with reduced risk of other cancers. This is a good overview:
"Glucagon-like peptide-1 medicines and cancer": https://www.nature.com/articles/s43018-025-01110-1
lnsru|21 days ago
falcor84|21 days ago
And as for cure rather than suppression - yes, according to that definition, no medicine that is intended to be taken indefinitely to manage a condition is a cure. But nevertheless, high blood pressure medicine, statins, anti-inflamatories, HIV antiretroviral therapy, and many other drugs have saved many millions of people from an early death. We should keep looking for one-off "cures" for all conditions, but let's not limit ourselves to them.
gib444|21 days ago
The only way I found to reduce cravings is to be a hermit because there is food absolutely everywhere all the time
Cthulhu_|21 days ago
But for many it's considered a shortcut and there's a big network of dubious online shops and weight loss clinics that sell it. It's not unlike crash / fad diets in that regard.
Most people would already benefit from lifestyle adjustments, but those are hard to do for most people - for starters, most people don't even have regular eating habits to begin with, no baseline to even make adjustments to.
vman81|21 days ago
bryanlarsen|21 days ago
lesostep|20 days ago
I quite smoking with cytisine, a drug that basically makes nicotine useless by taking it's place. The pitch is that it's just easier to quite cytisine than nicotine, because unlike nicotine it leaves your system easily.
Wouldn't the same principle work with Mounjaro? Ease off the drug evenly, so you would wouldn't have to overcome big bad addiction all at once, instead you face just a bit of addiction one at the time.
cm2012|21 days ago
rramadass|20 days ago
Is India about to make Ozempic-like weight-loss drugs a whole lot cheaper? - https://edition.cnn.com/2026/02/07/india/india-semaglutide-p...
tsoukase|20 days ago
password4321|20 days ago
hippich|20 days ago
drcode|21 days ago
now, alcohol has become the least interesting thing in the world, I just can't make myself drink it, it is so strange
glp1guide|21 days ago
That said, there are some that have reported it also lessens desire for things they want to desire.
Did a writeup on this back in summer '25:
https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...
Paywalled so direct links to notable papers through the years below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504
https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218
https://pubmed.ncbi.nlm.nih.gov/36031011
https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505
https://pubmed.ncbi.nlm.nih.gov/39764175
https://pubmed.ncbi.nlm.nih.gov/39032839/
https://www.science.org/content/article/obesity-drug-cuts-op... https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei... (The science.org article is paywalled IIRC)
https://pubmed.ncbi.nlm.nih.gov/39535805/
https://pubmed.ncbi.nlm.nih.gov/39937469/
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
pixl97|21 days ago
jqbd|20 days ago
unknown|21 days ago
[deleted]
pyeri|21 days ago
- Intermittent fasting (16x8 or at least stop eating after sun down)
- Daily morning pranayama (or 'breath work' if you prefer that term)
- Daily morning intake of copper utensil stored water (~8 hours or overnight)
- Weekly oil pulling for gum health.
This approach feels a bit stoic and neanderthal initially, less attuned to our modern and progressive society, but as effective as Ozempic in long-run (minus the side-effects or addiction).