[glp1guide]

No one knows of course, but it's looking likely -- anecdotal data is piling up.

That said, there are some that have reported it also lessens desire for things they want to desire.

Did a writeup on this back in summer '25:

https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...

Paywalled so direct links to notable papers through the years below:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504

https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218

https://pubmed.ncbi.nlm.nih.gov/36031011

https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505

https://pubmed.ncbi.nlm.nih.gov/39764175

https://pubmed.ncbi.nlm.nih.gov/39032839/

https://www.science.org/content/article/obesity-drug-cuts-op... https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei... (The science.org article is paywalled IIRC)

https://pubmed.ncbi.nlm.nih.gov/39535805/

https://pubmed.ncbi.nlm.nih.gov/39937469/

Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.

Eli Lilly has taken to calling GLP1s "anti-hedonics" as well

[pixl97]

This brings up another interesting question. What is the chemical basis of desire in the brain?

[torusle]

Easy, it is dopamine.