[dynm]

I'm surprised that this article doesn't appear to mention the RCT on semaglutide and alcohol use disorder by Hendershot et al. that was published in JAMA Psychiatry in early 2025 (though it's possible I missed it) https://doi.org/10.1001/jamapsychiatry.2024.4789

This was largely portrayed as a great result in the popular press although personally I think it was a bit of a disappointment given all the amazing anecdotes https://dynomight.net/glp-1/

[llm_nerd]

What made it a disappointment? Over only 9 weeks, which is a very short time for habit changes to take hold, there were measurable, statistically significant effects. And at the highest dose was just 1mg / week for one single week at the end, where the maintenance mode for many is 2.4mg / week.

Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.

[dynm]

The results for how much people actually drank in daily life were basically zero. No effect at all. The effects you're talking about are for a weird lab experiment where they sort of had people sit there in the lab and drink (or not). A huge percentage of people declined to participate in that experiment, too, which makes causality non-obvious.