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Balgair | 18 days ago
But these are powerful medications that affect very highly conserved areas of tetrapod biology. We discovered GLPs in the mouths of gila monsters, after all. So you then can infer that that the mechanism is at least 300 million years old (our last common ancestor with lizards).
Actually, I tried looking this up, and glucagon is likely 5-600 million years old, back to all chordates, the Cambrian explosion essentially, though likely even before that. So, incredibly conserved. Like, if you are a multicellular animal, odds are you have some glucagon-like thing for digestion regulation.[0]
We're strongly messing with a system that is just tremendously old. Biology and evolution are ruthless about this stuff, it edits it out as fast as it possibly can. That it's been so closely held is a very big sign for us that we need to tread extremely carefully.
Like, clearly, other countries do not have these issues with weight. Yes, they are developing them, I know. But even the US didn't have these issues near as bad just two generations ago, a blink in biological terms. You and I both know that the solution is not a pill, but the root cause of the obesity epidemic itself. These injections and pill are just band-aids for a much deeper and more pernicious problem.
But then again, you and I both know that we're not going to get at the root cause anytime soon either.
[0] This is biology so you'll find exceptions everywhere though
Izikiel43|18 days ago
As long as you have descendants, biology and evolution don't care, once that's done it's game over for them.
> That it's been so closely held is a very big sign for us that we need to tread extremely carefully.
It's been tested for over 20 years, the weight loss bit is the recent one.
> other countries do not have these issues with weight.
Yes they do, some are much worse than the US (https://data.worldobesity.org/rankings/), there are a lot of countries above 30% obesity rate.
> both know that the solution is not a pill
It's part of the solution, is how you help existing people with the issue.
Doing a restrictive diet is not easy (I know, I've been dieting since october, lost 15 pounds, but I can go on autopilot for this, which is not the case for others), it requires a lot of discipline that most people don't have, and our bodies are optimized to store calories, as well as being very efficient in consuming them, because for most of history famines were common, last ~100 years being the exception to the rule for most of the world population.
Future generations can be helped by better food culture and education, and that's the other part of the solution, long term.
sylos|18 days ago