[soperj]

You can do layouts with javascript?

Couldn't imagine ever wanting skip grid and flexbox for whatever has been concocted up for JS.

[tracker1]

multi-window interfaces in the browser... simulating a desktop, or other user navigable environment such as in a game or simulation, where a user my want to customize their environment beyond a grid snap.

[ReaderOfRunes]

The issue then becomes how do you make it accessible to screen readers? It's not impossible, just very tedious and requires cross browser and cross-device testing