[Amezarak]

High end estimates of people killed due to the deliberate spread of disease are dozens to hundreds. The pre-real-contact wave was obviously many orders of magnitude more deadly. Even your own link mentions one reason it was ineffective was prior exposure.

[luqtas]

the vast majority of indigenous people died on the 1° 100 years of colonization (from 1500 (when America was "found") -> 1600); the number goes up to 80 million people dead... the paper i mentioned says partial immunity didn't taking effect on a war past 1700! do you really think pox wasn't abused the time they were killing millions of natives per year? that's what i'm reffering to, not (somehow) recent wars

[Amezarak]

Yes, there is no credible evidence of your claim. The big disease waves stuck most natives before they ever saw a European, after contacted peoples caught disease in the normal fashion. The very few later documented attempts we have are almost completely ineffective, and often from people in a very desperate situation (e.g., besieged and dying of smallpox) - just a last ditch gambit that never accomplished its goal.