[greygoo222]

Sigh. Sure, if you had a gun to your head and you knew nothing else, it would be better to guess that a given population (hunter-gatherers) with low rates of some illnesses (T2D, HBP) also had low rates of another illness (CRC) than the reverse. Okay. That's a slightly better-than-chance guess, not anywhere near a solid basis for speculation.

"Anyways, it makes sense that marathoners get CRC because hunter-gatherers probably don't run that much" is bongcloud lalaland tier guesswork.

[inglor_cz]

"makes sense that marathoners get CRC because hunter-gatherers probably don't run that much"

That is a misinterpretation of what I wrote. Let me reformulate.

"Marathons are so much more extreme than what we used to do in the Stone Age, that some pathologies resulting from such long-term physical overload are to be expected." I don't see anything lala about that. You do extreme things, you reap some consequences, sooner or later.

I would say that marathons go beyond our design parameters, but my experience in HN is that the "design" metaphor always conjures some people who consider it a dog-whistle for intelligent design (as opposed to evolution), not just an imprecise metaphor, as metaphors usually are. So I avoid it in order not to attract a senseless fight.