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dakolli | 3 days ago

Not everything can be understood through p values and studies with 13 PARTICIPANTS undergoing a ONLY TWO EXPERIMENTS each, nor should the observed effects on 13 PEOPLE (half placebo) be extrapolated out to justifying safety for hundreds of millions of people. Next time you want to prove a point, take the time to research good sources, and not just ask an llm use your brain for once.

Please go put your kid on amphetamines for 15 years and let me know how that works out for them..

Do you care how much incidents of psychosis it causes on a yearly basis?

I said that the Ruling class (aka these professors) are pushing an agenda, and then you choose to provide evidence published by the ruling class to support that agenda.

discuss

cluckindan|3 days ago

You did understand that the parent post was referring to the referenced articles within the linked article?

14: https://journals.sagepub.com/doi/10.1177/1087054711427299 - N=50

54: https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.12917 - N=82

55: https://www.sciencedirect.com/science/article/abs/pii/S01497... - review of 21 studies

dakolli|3 days ago

Often prescribed to treat attention-deficit/hyperactivity disorder, the risk was highest in those taking 30 mg or more of dextroamphetamine (which corresponds to 40 mg of Adderall),

The researchers identified 1,374 cases of individuals presenting with first-episode psychosis or mania, compared to 2,748 control patients with a psychiatric hospitalization for other conditions like depression or anxiety. They conducted a comparison analysis of stimulant use over the preceding month and accounted for other factors, including substance use, in order to isolate the effects of stimulants.

They found the attributable risk percentage among those exposed to any prescription amphetamine was nearly 63 percent and for high dose amphetamine was 81 percent. These findings suggest that among people who take prescription amphetamine, 81 percent of cases of psychosis or mania could have been eliminated if they were not on the high dose. While a significant dose-related risk increase was seen in patients taking high doses of amphetamine, no significant risk increase was seen with methylphenidate (Ritalin) use, which is consistent with previous research, including a 2019 study led by Moran.

https://news.harvard.edu/gazette/story/2024/09/high-doses-of...

Among 1,374 case subjects and 2,748 control subjects, the odds of psychosis and mania were increased for individuals with past-month prescription amphetamine use compared with no use (adjusted odds ratio=2.68, 95% CI=1.90–3.77). A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

I don't care, the drug isn't safe. I've seen it permanently change many people. I don't care if they handpicked <100 individuals to prove safety. The doses cited above >40mg are pretty typical.

brailsafe|3 days ago

I think your take is a bit alarmist, if I were to be generous. On one hand, ya it's a pharmaceutical empire, but on the other, that empire's conduct is as detrimental to the people that actually do need those medications as they are to the people that might not. Nobody should be forcing their kids to take anything, but if a kid is struggling, it should be an accessible option, and it will probably help them get by in a system not designed for them. There's no reason to suggest that the general case is that a parent or some company is force feeding their kid meth.

I'm one of those people that could have benefited from it MUCH earlier, it's also incredibly boring if you get the right one. I have no idea what they really do for people who don't have ADHD, but for me it basically lets me get places on time and have a passably productive day. It's also not that trivial to get depending on where you live, and potentially expensive.

> Please go put your kid on amphetamines for 15 years and let me know how that works out for them..

Please tell someone who's gone from having 7 jobs in 7 years to 1 job for 3 years that they don't need it.

We can have issues with the implementation, that's fine

dakolli|3 days ago

Well I'm glad you haven't had any major side effects, just know you're playing Russian roulette with your sanity, and the way you perceive reality.. I'm not exaggerating here, give it a decade..or don't

And you're kind of confirming my original thesis, that its a class of drugs created by the ruling class for the working class to make the best workers for capital/ruling class, which it seems to have accomplished that in your case...

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

toast0|3 days ago

I've heard anecdotal reports from many people with ADHD symptoms that stimulants (caffiene, ritalin, street drugs) do help them focus. And quite a few from people with ADHD symptoms that stimulants make things much worse. And there's also reports that the stimulants help with focus but cause other problems.

If you're using chemical interventions for ADHD symptoms, you've got to be evaluating the response as well as getting feedback from the patient. Starting with small doses when possible is probably advisable.

Many symptoms can be addressed by behavioral and environmental/situational changes rather than chemical intervention, but chemical interventions can be effective for many, even if they're not effective for all.

dakolli|3 days ago

stimulants help everyone focus if dosed correctly!! I never said that it doesn't have that effect. I'm just arguing its very bad for the brain, and it mostly just benefits your employer/future employer at the risk of you going literally insane. Its a tool for Empire/Capital. Its very common for Empires to dose their working class on stimulants to achieve certain goals. It may help you but you're also risk of getting amphetamine induced psychosis, which should void any potential gain for any reasonable person..