[yunnpp]

The type hints are not even enforced at runtime. They are mostly documentation.

[LtWorf]

They can be used at runtime though. I wrote typedload, to load external data (json/bson/yaml) into python typed objects. In this way you know that if the data doesn't match the expectations you will have an exception at a specific point in the code, and after that it's safe to use the objects, rather than having to manually check at every access.

Now there are several other libraries that do this thing, but at the time (python3.5 and 3.6) it was the only option.