[jisaacstone]

I have a 30in monitor and I put all fonts at 16+ pt so they are easily readable from a distance, then I relax instead of leaning in toward the screen. I am often mentally tired at the end of day but no eye strain.

When I work remote using my laptop I always end with a headache and often tired eyes as well.

Many many hackers at my office use 3 column tmux or screen terminal sessions all day long on 11 in laptop screens, but monitors are cheap so why strain your eyes?

As others have mentioned check on ambient lighting and brightness settings. You may also want to try setting your white balance, contrast and saturation levels. Factory defaults are for making them look good in on display in a store, not for daily use.