Christian Schafmeister and Robert Strandh (creator of work-in-progress SICL, which Christian now uses in Clasp), both took on the multi-year project of creating a new CL implementation; Robert completely from scratch, Christian leveraging the high-level parts of an existing implementation, while completely rewriting the low-level ones.
I have a lot of respect for these guys; I had a few new ideas for ways of implementing Common Lisp, but decided not to when I realized with the amount of free-time I have, it would be about a decade of work.
I've spoken to Robert online, and he mentioned that a lot of people told him a from-scratch implementation was doomed to fail. The only reason those people were wrong was in that they underestimated his tenacity.
Hi, I'm Christian Schafmeister. Thank you so much for the nice comments! I just want to point out that this work was all done with your tax dollars. This work was made possible by support from the National Institute of Health (NIGMS), the National Science Foundation (NSF) and the Defense Threat Reduction Agency (DOD:DTRA).
If you read the Feynman speech that he references at the beginning, he actually mentions that as you scale machines down, things like mechanical rigidity will degrade and you will need to change your design rules accordingly. I always assumed that when you reach the molecular level, thermal motion and the constant bombardment by water molecules would mean that the only viable option is to use proteins, just like nature does, so it's very interesting to see that this guy is aiming to use more rigid structures at the molecular level. I guess this is a way to reduce the complexity (degrees of freedom) compared to designing protein tertiary structure. I wonder if this is too constraining though, he admits he has yet to figure out how to build mechanical machines using this approach, and intuitively I'd expect that to be very difficult with this degree of rigidity. You might need the additional flexibility of peptide chains to do many of the interesting things that are possible.
He does point out the advantage of durability, but this raises the obvious issue that one of the questioners alluded to, namely toxicity/pollution risk. I'd think degredation by biological or other means would be a feature, not a bug, since as he points out, even conventional plastics are a huge pollution problem.
Christian Schafmeister here - thanks! You make some very good points that I can address:
(1) Things made with "Molecular Lego" still move, but they keep their shape just enough to organize atoms/groups to do things like speed up reactions and bind other molecules. We've explored dynamics in several of our papers. They aren't too constrained - they are constrained "just enough"; and we can build in flexibility and hinges where ever we want.
(2) We don't know how to make mechanical molecular machines with them yet; we need to start making a lot of them and explore their properties to figure that out. The first folks who smelted iron didn't know how to build motors with it - it took a lot of people playing around with iron for a long time to figure that out. I think we can get there in less time but it will take work.
(3) Re: toxicity/pollution - this is the first non-natural molecular technology that contains the solution to any problems that it generates. We need to learn how to make catalysts well and then we can build catalysts that break these molecules down. Conceivably, we could build materials that contain the catalysts that break them down and are activated by an external signal. Or we make materials out of bigger bricks (built from Molecular Lego) and we fish them out of the environment, tear them apart from each other, check them for defects and build new materials with the good ones and recycle the broken ones. We can also build catalysts that break down every other indestructable material that we've been dumping into the environment for 100 years. Regarding toxicity, these molecules are made out of carbon, nitrogen, oxygen and hydrogen - the same atoms you are made out of. They are inherently non-toxic (there are qualifiers on this).
Do any of this from scratch and your productivity will plummet:
LLVM for compiling; Boehm for garbage collection; GMP for bignums; Readline for interactivity; C++11 for ... cough ... oh will you look at the time---lesson is over for today, grasshoppers!
[+] [-] aidenn0|10 years ago|reply
I have a lot of respect for these guys; I had a few new ideas for ways of implementing Common Lisp, but decided not to when I realized with the amount of free-time I have, it would be about a decade of work.
I've spoken to Robert online, and he mentioned that a lot of people told him a from-scratch implementation was doomed to fail. The only reason those people were wrong was in that they underestimated his tenacity.
[+] [-] drmeister|10 years ago|reply
[+] [-] PuercoPop|10 years ago|reply
[+] [-] bratsche|10 years ago|reply
[+] [-] dekhn|10 years ago|reply
[+] [-] mark_l_watson|10 years ago|reply
[+] [-] graphene|10 years ago|reply
If you read the Feynman speech that he references at the beginning, he actually mentions that as you scale machines down, things like mechanical rigidity will degrade and you will need to change your design rules accordingly. I always assumed that when you reach the molecular level, thermal motion and the constant bombardment by water molecules would mean that the only viable option is to use proteins, just like nature does, so it's very interesting to see that this guy is aiming to use more rigid structures at the molecular level. I guess this is a way to reduce the complexity (degrees of freedom) compared to designing protein tertiary structure. I wonder if this is too constraining though, he admits he has yet to figure out how to build mechanical machines using this approach, and intuitively I'd expect that to be very difficult with this degree of rigidity. You might need the additional flexibility of peptide chains to do many of the interesting things that are possible.
He does point out the advantage of durability, but this raises the obvious issue that one of the questioners alluded to, namely toxicity/pollution risk. I'd think degredation by biological or other means would be a feature, not a bug, since as he points out, even conventional plastics are a huge pollution problem.
Fascinating stuff nonetheless.
[+] [-] drmeister|10 years ago|reply
[+] [-] istvan__|10 years ago|reply
[+] [-] BenTheElder|10 years ago|reply
[+] [-] sunkencity|10 years ago|reply
Macros are truly the way up if we are to escape the gravity well of calculus for bio chemistry. How else to gain delta v?
[+] [-] cracauer|10 years ago|reply
[+] [-] ris|10 years ago|reply
[+] [-] kazinator|10 years ago|reply
https://github.com/drmeister/clasp
Do any of this from scratch and your productivity will plummet:
LLVM for compiling; Boehm for garbage collection; GMP for bignums; Readline for interactivity; C++11 for ... cough ... oh will you look at the time---lesson is over for today, grasshoppers!
[+] [-] mahmud|10 years ago|reply
[+] [-] wtbob|10 years ago|reply
[+] [-] graovic|10 years ago|reply