anon192831's comments

Hopefully new upstarts with a vision for quality.

It seems that every brand starts out with noble intentions, then after rising to meteoric success, they get gutted and we have to wait for the new, high quality up start.

It's not just hitting the vacuum tube. If one just trips for the sake of tripping, then there is not much to be gained except for several hours of happy serotonin hits in the brain.

However, what we know about psychs is that there is a huge release of BDNF (brain derived neurotrophic factor) and a shutdown of the DMN.

The BDNF enables a ton of new neural connections to be built. It's like you have about 6-8 hours of a period where your brain plasticity goes back to that of an infant, just absorbing everything. So in this accelerated learning state, it's possible to work through one's emotions.

So it makes sense to prepare for several weeks to receive therapy and to outline goals and memories to revisit to process them during this heightened period. Then when the drug wears off, you're still left with the new neural connectivity and perspectives and the other benefits that were derived from the session.

Rather than hitting the vacuum tube, this is more like re-running the radio scanner in your car to find radio stations when you've moved over to a new city and the old radio stations are now out of range while one isn't tuned to the current set of radio stations.

CBD is not psychoactive. So generally no. However CBD can have THC alongside it, which could have the anxiety/paranoia effects.

If you can find access to a psychedelic like LSD/mushrooms, it is more likely a far more effective treatment for anxiety & depression than any SSRI's available.

Microdoses can be very effective and a regimen only needs to last a handful of doses and stopping would have very little side effects. As long as authenticity of the substance can be proven, generally psychedelics are very safe, especially at microdose levels.

A little googling for psychedelic + depression will provide data. A couple of research/articles below.

https://journals.sagepub.com/doi/pdf/10.1177/026988111667551...

http://www.biblioteca.cij.gob.mx/Archivos/Materiales_de_cons...

https://www.google.com/amp/s/amp.businessinsider.com/psyched...

It seems challenging as full-cotton shirts seem to be more prone to shrinkage and aren't necessarily as soft and resilient like the cotton/poly blends that are all so prevalent in just about every fabric out there.

perhaps it's possible that it's not enough to be dangerous in isolation, but perhaps significant enough for those that already have a lot of existing dna damage (e.g. late stage cancer patients and elderly).

Korea has a different system where they don't pay rent, but they pay what's called jeonse (jun-sae). You pay about 33-50-60% the value of the property and live rent free for 2 years. At the end of the 2 years, you get your lump sum back.

The idea is that the landlord makes their money by investing the lump sum, though there seems to be risks where the landlord is unable the cough up the money at the end of the term and needs to find someone else to cough up jeonse money to pay back the original tenants.

Of course many tenants can't come up with 33% of a property, so they are also taking out a loan to come up with the money and making payments on that money to which essentially comes out to rent, but significantly cheaper.

It does seem that rent is becoming far more common in Korea now, so jeonse may be on its way out, but it is a different system, can't say that it's better or worse.

Of course victims should not have to bear the responsibility, yet it's an unfortunate state of affairs that we must rely on victims in order to bring justice and awareness.

Not sure how YC would go about proactively screening away bad actors. Most of these people tend to be powerful/rich enough that they very likely are not on any lists to be weeded out from the get go.

Sure the (potential) victim shouldn't have to do anything and have a safe environment available, yet the mechanism for determining a group's sex-abuse-potential social credit/standing doesn't currently exist en-masse, neither would most of the population want a sex-assault-credit-score.

In your scenario, potential bad financial actors can be screened a la concrete behaviors. Did the VC write the check or not. Does the VC have the balance to show in their bank account. Are they in breach of contract? Even if there were bad financial actors, an anonymous list to report such behavior is not without merit. It could be a useful way to bring a class action to a bad actor without tipping off the bad actor from running away. Then the flip side is, "you are otherwise upstanding, but our list says you looked at a female in a creepy manner 10 years ago, so we don't want your investment."

In the case of sexual assault, there's varying degrees of behavior depending on context that may or may not constitute get-on-a-sexual-assault-list behavior. This grayness makes a list hard. Usually, egregious acts are easy to judge by. However, more subtle acts have a shroud of plausible deniability... "We were sort of seeing each other and a partner was unsure about a guy/girl, but decided to feel him/her out on some dates... and also he/she could make a vc intro didn't hurt..." How quid pro quo is this? It's perfectly plausible that the individual in my hypothetical situation is an upstanding person and truly was attracted and only made a single attempt at someone they liked, or it could be that this individual is a serial hit-on-potential-founders, but doesn't necessarily do enough to actually get charged with sexual assault/rape, but probably should be barred from being an investor.

The research does show that offenders tend to be repeat actors. Building such a list seems like the step in the right direction. The existence of the list itself does serves as a potential deterrent. It usually isn't until multiple victims come forward where the perpetrator does not have much anything to hide behind as a she-said/he-said debate. Thus potentially getting on the list is something perpetrators need to consider before acting badly.

The justice system is innocent until proven guilty, thus an actor must broach a line before they can be dealt with. Unfortunately, it's only the victims that do have the power to bring awareness to the existence of their perpetrators. Every resource we can dedicate to enabling victims is a step closer to where we should be going.

I have a brother in-law (20yo) that's also on the spectrum (aspergers).

In an attempt to help with general anxiety that's associated with Aspergers, we introduced him to marijuana (as it has a relaxing effect), but that just mainly causes more anxiety.

However, it turns out that microdosing on psychedelics has been quite the panacea. I'd highly recommend reading the book "A Really Good Day" that goes over the safety aspects, myths and such.

In a span of 4 months, the kid is completely changed. Far more sociable. He's communicated that his anxiety is gone. He has become more thoughtful and far more self-sufficient. His ability to communicate/articulate his needs & desires, relay stories from his day are new behaviors that have presented himself since this regimen has started. In a sense, he has gone from "more autistic" to "more typical teenage/young adult boy" in a span of 4 months. He still does say that his condition is still apparent and that his ability to intuitively react to emotion/facial expressions/body language hasn't necessarily developed, but with the anxiety removed, now he can read body language cues with ease as he is not debilitated by the anxiety of the interaction and move forward in the interaction rather than recusing himself and living in his own bubble.

The reason this appears to work is because psychedelics increasing brain plasticity/neurogenesis. Even after the doses stop, the benefits will continue to remain as new neural connections have become established. A regimen can be used for say a month or two and be stopped with the benefits derived, so it's not something one necessarily needs to engage in for the rest of their life.

His immediate family doesn't know that this regimen is taking place, but everyone in the family during gatherings attributes his demeanor change to his "summer job" which "opened" him up, and are so "proud" of him and his growth. Of course, spending 12 years in a social school environment did nothing to open him up, but a 3 month summer job did the trick. chuckles

Of course there are stories of people who have taken very large tripping doses and have had catastrophic effects, so it isn't without risks, however, it appears that the risks are pretty minimal and also very manageable at microdose quantities.

So far in my microdose experiment, n=5 have had absolutely no ill effects and has been tremendous boon to mental state/cognition/clarity in general.