cathedral2's comments

cathedral2 | 4 years ago | on: Around one-in-three children globally suffer from lead poisoning

No, not healthy at all. There is a condition known as Gadolinium Deposition Disease (GDD) that some people are developing from the retention. The mechanics are not fully understood, and there is a multi-billion dollar industry preventing (or at least not encouraging) any serious inquiry into the matter, but my understanding is that if your body views gadolinium as a threat (similar to an allergy), it will mount an immune response against it. However immune responses are futile against heavy metals. So think of it as a permanent, never-ending allergic reaction to an element that refuses to leave your body.

cathedral2 | 4 years ago | on: Around one-in-three children globally suffer from lead poisoning

There's a new drug emerging from Berkeley and a company spawned from there called HOPO [1]. The drug is a chelator that has a special affinity for heavy metals in the lanthanide group, which happen to be some of the more toxic metals. This includes gadolinium, which is found in MRI contrast agents, and has been known to cause many-year retention in the bones and skull [2] from just a single dose.

"The chelating agent 3,4,3-LI(1,2-HOPO) has been specifically optimized for the selective binding of heavy metals, and it promotes their rapid removal from the body. Unlike other chelating agents, it does so without depleting the body of essential mineral elements such as zinc and calcium."

They were initially focused on gadolinium but have recently pivoted to lead poisoning as a seemingly more addressable market.

[1] http://www.hopotx.com/science/

[2] https://www.fda.gov/drugs/drug-safety-and-availability/fda-d...

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