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chimichangga | 6 years ago | on: FDA: Emergency authorization of Hydroxychloroquine for Covid-19 treatment

"The U.S. Department of Health and Human Services (HHS) today accepted 30 million doses of hydroxychloroquine sulfate donated by Sandoz, the Novartis generics and biosimilars division, and one million doses of chloroquine phosphate donated by Bayer Pharmaceuticals, for possible use in treating patients hospitalized with COVID-19 or for use in clinical trials. These and other companies may donate additional doses, and companies have ramped up production to provide additional supplies of the medication to the commercial market."

chimichangga | 6 years ago | on: Ask HN: Who is hiring right now?

Let's Support the Country: Who’s Hiring In The Coronavirus Economy.

Zoom, 2,400-person video conferencing company has 235 open roles in sales, support, marketing, HR, Finance, engineering

https://www.forbes.com/sites/alexandrasternlicht/2020/03/20/...

Amazon is hiring 100,000 workers, Walmart is hiring 150,000 — here are the sectors adding jobs amid coronavirus

https://www.marketwatch.com/story/amazon-is-hiring-100000-wo...

Domino's hiring 10,000 employees amid coronavirus demand surge

https://www.foxbusiness.com/markets/dominos-hiring-coronavir...

CVS to hire 50,000 workers, gives bonuses to employees amid coronavirus pandemic

https://www.usatoday.com/story/money/2020/03/23/cvs-health-h...

Dollar General Add 50,000 Jobs

https://www.forbes.com/sites/alexandrasternlicht/2020/03/20/...

7-Eleven, an international convenience chain with more than 70,000 stores, announced Friday it will be hiring as many as 20,000 store employees.

Kroger is hiring 10,000 new associates nationwide across retail stores, manufacturing plants and distribution centers

Safeway, a national grocery chain, is looking to fill 2,000 new jobs located mainly in California.

chimichangga | 6 years ago | on: Chloroquine, past and present

Also, Bayer thinks there's enough merit to this to issue their own press release and donate 3M pills.

"New data from initial preclinical and evolving clinical research conducted in China, while limited, shows potential for the use of Resochin in treating patients with COVID-19 infection.

Bayer in recent days has been in talks with the White House, HHS, CDC, and the FDA, offering any assistance we can provide with a focus on donating Resochin to help in the government’s efforts to combat the virus.

Currently not approved for use in the United States, Bayer is working with appropriate agencies on an Emergency Use Authorization for the drug’s use in the U.S.

Bayer thanks the Trump administration for moving quickly to enable this donation and will continue to work closely with the administration to support its efforts in the fight against COVID-19."

https://bayer2019tf.q4web.com/news/news-details/2020/Bayer-P...

chimichangga | 6 years ago | on: Chloroquine, past and present

"Two drugs, chloroquine and remdesivir, are being designated for Expanded Access, or “compassionate use,” by the FDA."

It's already available. Hopefully soon to the general public (it's prescription only btw).

chimichangga | 6 years ago | on: Bayer donates 3M chloroquine phosphate tablets for potential Covid-19 treatment

He didn't "say it's out there". Bayer did, who apparently think there's merit to this enough to issue a press release of their own and donate 3M pills. Bayer probably knows more about this than you.

Also, reuters, cnn, msnbc, etc. covered it.

Making the info available here in HN is not tantamount to telling people to self-experiment. that is laughable.

chimichangga | 6 years ago | on: Severe Outcomes Among U.S. Patients with Covid-19, Feb 12–Mar 16, 2020

https://en.m.wikipedia.org/wiki/Chloroquine

For coronaviruses chloroquine works by increasing endosomal pH and interfere with terminal glycosylation of the cellular receptor.[42][43] In late January 2020 during the 2019–20 coronavirus outbreak, Chinese medical researchers stated that exploratory research into chloroquine and two other medications, remdesivir and lopinavir/ritonavir, seemed to have "fairly good inhibitory effects" on the 2019 novel coronavirus. Requests to start clinical testing were submitted.[44][45][46] Chloroquine phosphate had been also proposed as a treatment for SARS-CoV with in vitro tests successfully inhibiting the virus.[47]

On 19 February 2020, preliminary results found that chloroquine may be effective and safe in treating COVID-19 associated pneumonia.[48][49] There is evidence to indicate the efficacy of chloroquine phosphate against SARS-CoV-2 in vitro, on Vero cells.[50] The Guangdong Provincial Department of Science and Technology and the Guangdong Provincial Health and Health Commission issued a report stating that chloroquine phosphate "improves the success rate of treatment and shortens the length of patient’s hospital stay" and recommended it for patients diagnosed with mild, moderate and severe cases of novel coronavirus pneumonia.[51]

Chloroquine have been recommended by Chinese, South Korean and Italian health authorities for the treatment of COVID-19 [52][53][54], however they have noted the important contraindications for people with certain heart conditions, diabetes, etc.[55][56] In February 2020, both drugs were shown to effectively inhibit COVID-19 in vitro [57], however a further study concluded that hydroxychloroquine was more potent than chloroquine, with a more tolerable safety profile. [58] Preliminary results from a multicentric trial, announced in a press conference suggested that chloroquine is effective and safe in treating COVID-19 associated pneumonia, "improving lung imaging findings, promoting a virus-negative conversion, and shortening the disease course".[59]

On 16 March 2020, advisor to the French Government on COVID-19, Professor Didier Raoult, announced that a trial involving 24 patients from the south east of France supported the claim that chloroquine was an effective treatment for COVID-19.[60] 600mg of hydroxychloroquine was administered to these patients every day for 10 days. The drug appeared to be responsible for a "rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious".[61] The study also suggested that taking chloroquine in combination with the antibiotic azithromycin - which is known to be effective against complications from bacterial lung disease - led to even better outcomes. Professor Raoult said the results showed there was "a spectacular reduction in the number of positive cases" with the combination therapy.[62] At 6 days, among patients given combination therapy, the percentage of cases still carrying SRAS-CoV-2 was no more than 5%.[63]

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