jeejayisbusy | 4 years ago | on: AlphaFold-Powered Drug Discovery of a Novel CDK20 Inhibitor
another important point to notice is affinity. While 8 uM looks impressive, it is not that hard to develop such potency since compounds are likely to aim ATP binding pocket. It is big, deep and offers many hydrogen bond donors in hindge region. What important for such compounds is selectivity, since you want to inhibit only specific kinase, not all of them.
For me it looks like advertising of their platform, not actual scientific achievement.