meneton's comments

A lot of Research into colony collapse is funded by agrotech.

No I'm here too. But we are not totally correlated. There is more correlation within you, than there is between you and me. We are both nodes in the universe's correlation network complex enough to model our own correlations.

I agree I didn't phrase that right. It was a short cut.

There has been debate over whether mitochondria can be called alive since at least 1890. For many years the vast majority of mitochondrial biologists have avoided the binary alive/not alive classification because there is a spectrum of 'livingness' and we can draw the line anywhere we like.

Picking a different line position is not scientific, it is semantics. What do we mean by the term 'alive'?

The article presented a profound new way of viewing the living state of mitochondria that was going to transform the world. It said nothing new, and failed to make any reference to the long term debate.

But it was a nicely written interesting article and mitochondria are going to be hugely important therapeutic area in the future.

Arguing about where you draw the line doesn't advance anything, it just muddies the water. We have robust definition of what is and isn't alive built by consensus. Mitochondria fall into the 'not alive' category by our definition. Presenting decades old scientific views as evidence that this categorisation is wrong doesn't add anything. This article has had far more exposure than some really groundbreaking science and it adds nothing.

As I said in another comment, I think that mitochondria are fascinating, understudied and a rich area for research.

We are bound to the myriad other pieces of DNA that all have different evolutionary histories within us, we are symbiotically bound to many strands of life on many levels. We are just one strand, a part of a singular whole, bound to all strands of life beyond us. This view of life led me to science. I totally think that this view of biology is not properly appreciated by most scientists.

But this article was presented as a scientific piece and made the explicit claim that mitochondria were alive which is a semantic argument that doesn't have a scientific answer.

It is a well written piece that made it to the top of hacker news and it's great to see the debate.

But it just isn't true that mitochondria are alive by our currently accepted definition of alive. This is an old debate in biology that was settled years ago. There is nothing in this paper that wasn't known to mainstream science decades ago, but it is presented as a novel scientific viewpoint.

I am not sure what exactly the 'broad implications and worldview' are here that are being challenged. The article is presented as a scientific opinion and references scientific research and has a doi number for citation (Cite: Liyam Chitayat. “Mitochondria Are Alive” Asimov Press (2024). DOI: https://doi.org/10.62211/38pe-75hu). What do you think that the article was challenging?

You are completely right that we should be thinking far more creatively about manipulating mitochondria. There are a lot of diseases (including Covid) that have mitochondrial aspects. I just don't think calling them alive helps, other than to get you some decent exposure on HN :)

This article is framed as if there is something novel and profound here, but the "aliveness" of mitochondria is simply a matter of how we choose to apply the label "life" - a human linguistic construct that exists independently of the biological phenomena. This is not a new discussion - science has been considering this question for many decades, just as it has with viruses. These all come down to arguments about semantics and don't add anything to the science.

Mitochondria are fascinating and there is still a huge amount to learn about them but they are totally dependent on the cell's machinery. Most of their genes, the code for their structure, are in the nuclear DNA. A glaring omission if you are trying to make the case that mitochondria are independently living. My heart can exist independently of me, and be transplanted into other people, but does it mean that it is alive?

The implication of the whole article is that there something we have missed. This really isn't the case. Lynn Margulis's endosymbiotic origin of mitochondria was challenged by many, and it did spark a scientific debate - that's how science works. She won the argument comprehensively decades ago and is well established science. There have been many such endosymbiotic events in the history of life - there are subfields of evolutionary biology that study these processes.