mjewkes's comments

The claim is largely true for drug development, but not for routine procedures. Those are expensive for unrelated, and largely pathological, reasons.

I work in the drug development industry, its a shame this has been downvoted, it's largely true - at least for new drug innovation. The fact that routine procedures are expensive in the US is unrelated.

The US is ~35% of the global pharmaceutical industry, which is the topline driver of new drug development.

When the US pays top dollar for new drugs, it does effectively subsidize European access to the new research.

>Do you have any data to backup your claim?

I would suggest https://www.rand.org/pubs/research_briefs/RB9412.html

or the Great American Drug Deal, by Peter Kolchinsky.

>Do you have any data to backup your claim?

I would suggest The Great American Drug Deal, by Peter Kolchinsky.

Also - https://www.rand.org/pubs/research_briefs/RB9412.html

>For example Cuban healthcare/treatment/outcome is excellent based on its own research

Cuba does not contribute substantially to global pharmaceutical research.

>Roche(Swiss) nor Merck ( German, not related to US Merck) don't benefit much (if at all) from US subsidies.

Roche makes 55% of its revenue from US drug sales (https://assets.cwp.roche.com/f/126832/x/db9d31e8a7/fb20e.pdf p22)

EMD Serono (formerly Merck KgAA) is similar.

These revenues are the topline driver of the drug development industry.

Does anyone here recommend a modern-ish guide to GRF/settings/Gamescripts?

It seems like there are so many features like CargoDist/FIRS/City growth - many of which are "essential", but don't play well together, or have questionable balance.

Exact phrase matching is what google (sometimes? used to?) do for you if you put your search terms in double "full quotes".

It returns only results that contain the exact multi word sequence in exactly the same order.

ILIKE itself is a linear scan. The only way to index them are trigram indicies, which are very inefficient (and sometimes not usable) if you're searching document-length content.

Whether or not it works in your specific situation depends on your use case.

Try https://simonwillison.net/search/?q=%22your+own+benchmarks%2...

Looks like we get 37 results, of which 2 are true positives.

Looks like "your" and "own" are both contained in the english.stop stopwords list. So you could fix this by removing stopwords from your dictionary.

While disabling the stemmer is relatively easy (use the 'simple' language setting for your ts_query), altering the stopword dictionaries is more involved, and not easy to maintain or pass between developers/environments, and not at all easy to share between queries.

And so the most common suggestion is to use ILIKE.

Lucene has no problems with any of this.

Exact phrase matching. This generally requires falling back to ILIKE, which is not performant.

Where have we seen this? Genuine question.

>3. The renewables industry likes to downplay the sheer volume of fossil fuels required to manufacture the parts. The energy ROI on this is quite poor, and in many cases, we would have been better off skipping the intermediate step and burning the oil and gas directly.

I'm assuming you're referring to Ferroni and Hopkirk (2016) which claimed ERORI of ~0.8-1.7.

You should be aware that their work has been pretty thoroughly picked apart - the rebuttal produced immediately after the above, by 27 international scholars, suggests a ERORI of 7-8. It has likely improved since that time.

https://www.sciencedirect.com/science/article/pii/S030142151...

The top comment on the article itself suggests that the UK’s betting markets don’t have the problems that limit PI.

They are currently +-0.05$ of PI. A material but not enormous difference

Motion Twin is the classic example in the games space http://motion-twin.com/en/

They shipped Dead Cells, which is rated as "Overwhelmingly Positive" "96% of 50,435 reviews" on steam.

https://store.steampowered.com/app/588650/Dead_Cells/

The HaXe programming language originally came out of Motion Twin, although Nicolas Cannasse has since left to do his own thing.

Strilanc, who works on the google quantum team, has a simulator here: https://algassert.com/quirk

0.046%

You didn’t multiply by 100 to change from per unit to per cent.

Still bad though.

Conversely, I'd love to read a Vox editorial that looks for opportunites for government deregulation/step-back.

In their public-facing work, Cowen and pc talk primarily about the importance and upside of progress and growth [1][2]. As someone who leans left, I find these writings both novel and compelling - some of the most compelling market-oriented thinking I've come across.

At the same time, pc, Cowen, and Zuck are in the thick of the SF "conservative libertarian" milieu. Thiel was a/the first major investor in FB, Stripe, and Cowen's "Emergent Ventures". Cowen's Mercatus center has deep ties (that I don't fully understand) with Koch industries and the federalist society. Etc.

I'm _far_ less impressed with the policies actually advocated for by these groups.

I'd actually be really interested in hearing the three of them discuss opportunities for government policy to have significant positive impact. I'd be surprised if pc wasn't a fan of at least some aspects of the FAA / NTSB [3], and I know Cowen advocates for public increases in basic research / R&D investment [4].

As "libertarian conservative" "public thought leaders", I wonder where else they might agree that government intervention can be net very-positive.

[Edit: sorry about the labels. There are real clusters of thinking and people here that need names, but I'm sure that they'd prefer different labels]

[1] https://www.theatlantic.com/science/archive/2019/07/we-need-...

[2] https://www.amazon.com/Stubborn-Attachments-Prosperous-Respo... + thorough review/interview https://80000hours.org/podcast/episodes/tyler-cowen-stubborn...

[3] https://twitter.com/patrickc/status/1021995602970923010

[4] https://marginalrevolution.com/marginalrevolution/2013/02/th...

What's the best way to get in touch? I'm at username [-] google's email.

It's much older than that.

The first bulletproof vest dates to the 1890s, and the inventor photographed tests on himself for publicity.

https://culture.pl/en/article/the-monk-who-stopped-bullets-w...

A doubly linked list is not a good candidate to be written in _safe_ rust.

Lots of other problems are.

>why these highly experimental approaches (e.g reprogramming immune cells) can't be done in animals with cancer

They absolutely are, all the time. Animal testing is relatively cheap (esp. for mice) and widespread in biotech. It's generally hard to get an IND approval (step 1 of human testing) without successful animal tests.

Animal models, unfortunately, aren't super effective at predicting human outcomes.