mrestko's comments

mrestko | 4 years ago | on: California is shutting down its last nuclear plant

The first line of the article:

"California is not keeping up with the energy demands of its residents.

In August 2020, hundreds of thousands of California residents experienced rolling electricity blackouts during a heat wave that maxed out the state’s energy grid."

How can you say baseline power is not desirable?

mrestko | 4 years ago | on: Black mamba venom is 'better painkiller' than morphine (2012)

It's hard to know what the side effects are since it hasn't been tested in humans and is not in a form where it would be a useful drug. We've had plently of promising drugs turn out to have unexpected and sometimes devestating side effects when tested in humans.

mrestko | 4 years ago | on: Black mamba venom is 'better painkiller' than morphine (2012)

The title is not good--lots of meds are betting than morphine...that's why we have all the other opioids: hydromorphone, fentanyl, remifentinil, sufentinil, oxycododone, etc.

If you look at the Nature abstract linked from the news article, all they claim there is that the analgesic effects can be, "as strong as morphine."

This also a protein which is inherently more expensive and difficult to turn into a drug compared with a small molecule.

mrestko | 5 years ago | on: A 12.48 Inch (1304x984) Three-Color E-Paper Display by Waveshare

I recently bought a Boox Note 2 for this and it works very well. I had previously tried reading PDFs and technical documents on my Kindle but it was pointless since it was so small. The Note 2 is just a little smaller than regular letter size paper and it runs a full Android operating system so it's easy to get whatever document management system you want to use working on it (including the Kindle app).

mrestko | 5 years ago | on: Maillard reaction

Those eggs are not being levitated above the surface. I guarantee it. The pan would need be to be red hot to maintain the leidenfrost effect with a pan full of eggs. As anyone who has played around with the leidenfrost effect knows, since there is essentially no friction the little droplets of water skate around like pucks on an air hockey table. When you put your eggs in your hot pan cooking an omelette they do not float and flip out the side of the pan as they would if they were experiencing the leidenfrost effect.

mrestko | 5 years ago | on: Maillard reaction

No one cooks omelettes like that. Where are you getting that from? If you actually tried this you would end up with burned, acrid eggs.

mrestko | 7 years ago | on: How Did Our Medical Notes Become So Useless?

This goes back to the central thesis of the article: that interference from non-physicians (i.e. insurers, billers) are destroying the usefulness of notes.

Physicians are bound by both a professional duty and oath as well as legal liability to keep your medical information in the strictest of confidence. But it is nearly impossible to know in advance when a particular piece of medical information will become important for the treatment of a patient. Hiding it because of concerns about insurance or employment is not a solution--it's an indication that insurance and employment have undue influence on or access to a professional record.

mrestko | 7 years ago | on: Is the Alzheimer's “Amyloid Hypothesis” Wrong? (2017)

No it isn't. The Practice Guidelines from the American Association of Clinical Endocrinologists are summarized in this PowerPoint presentation from their website.[1] It is not intended for lay consumption, but you can clearly see that there is a large emphasis on diet changes and weight loss. However, as I mentioned in another comment, the reality in practice is that many people are either unwilling or unable to change their lifestyle sufficiently to reverse the condition.

Even before being diagnosed with a disease there are huge returns to regularly exercising and staying fit. You feel better, look better, have more energy, sleep better, the list continues. A doctor saying, "you need to lose weight and exercise, it could help with your diabetes," is a relatively small motivator compared with all of the other benefits.

1. https://www.aace.com/files/aace_algorithm_slides.pptx

mrestko | 7 years ago | on: Is the Alzheimer's “Amyloid Hypothesis” Wrong? (2017)

Current medical student here. We do learn about these things but a) the science is weaker than many areas of medicine because it is much harder to do randomized controlled trials of diet and b) patients will barely take a pill once a day for their blood pressure, much less entirely change their lifestyle.

mrestko | 8 years ago | on: Git Magic

Would be nice if you didn't have to scroll back to the top of the page to go to the next section. Otherwise seems like a good resource.

mrestko | 8 years ago | on: Formula E reveals second-generation car

Theoretically, if there was a short to ground, a voltage potential could develop between the two legs if the driver took a step away from the car. By hopping and landing with feet together, both legs will always be at the same potential so no current should run through the legs even if the immediate area around the car is energized.
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