ndynan | 1 year ago | on: FDA approves a novel drug for schizophrenia
ndynan's comments
ndynan | 1 year ago | on: FDA approves a novel drug for schizophrenia
Here is the drug trial results for EMERGENT-2 which was one of the two phase-3 trials that lead to the approval.
I think its striking that the trial is only 5-weeks long and this medication gets approval.
ndynan | 1 year ago | on: Knocking out one key gene leads to autistic traits
ndynan | 1 year ago | on: Viral DNA in the human genome linked to major psychiatric disorders
On very quick review, it looks like there are is significant association between HERV genetic factors and specific diagnoses given PIP. However, what's not clear to me is effect size or correlation coefficient.
I'm not sure if I'm missing this or it's not reports. There might be a relationship, but at a very small percentage.
ndynan | 3 years ago | on: Ask HN: Do I Have ADHD?
In my very humble opinion, the diagnostic category of ADHD isn’t particularly helpful, it’s too broad, one person with ADHD looks completely different from another. Additionally it’s very easy to identify and over-identify with diagnosis to the detriment of your personal potential. It’s a self-fulfilling prophecy and all to common trap.
As other have said, you can go see a psychiatrist and they’ll evaluate you and maybe you end up with stimulant meds. Attentional issues are not just due to ADHD, they can be part of anxiety, depression, PTSD, etc.
If you do get an ADHD diagnosis, The meds help some people (actually they make everyone focus, i.e. why they gave them to fighter pilots). They also suck for other people.
What I believe will be helpful is learning how to live your life with your unique mind. If you can find a therapist who practices mindfulness-based interventions, (ACT, MBCT, DBT) it could be incredibly beneficial. Good luck on your journey!
ndynan | 3 years ago | on: U.S. public health agencies aren't ‘following the science,’ officials say
"Then they ignored natural immunity. Wrong again. The vast majority of children have already had Covid, but this has made no difference in the blanket mandates for childhood vaccines. And now, by mandating vaccines and boosters for young healthy people, with no strong supporting data, these agencies are only further eroding public trust."
What the fuck is "natural immunity" when we have had 5 variants of omnicron and infection doesn't provide immunity to the other variants?
The real crime IMO, is that... U.S. Public Health Agencies Aren't ‘Following the Science,’... the science of how we could actually reduce spread and decrease the 350~ DEATHS per day adding to the more than 1 Million dead already.
ndynan | 4 years ago | on: Google Drive: Shortcuts replacing files and folders stored in multiple locations
I imagine this was a tough call for a PM, with a lot of cases to consider and account for given this is so embedded in the Drive product DNA.
ndynan | 4 years ago | on: Transit Panel
Looking at your building location, I see you're near the Hoboken stop. That's why you have the Hoboken departure times hard-coded in the departure_times.js.
I thought the file was just the line schedule and then you'd have to pick a station, but I see now it's just the schedule for the Hoboken station?
ndynan | 4 years ago | on: Transit Panel
ndynan | 4 years ago | on: Can medieval sleeping habits fix America’s insomnia?
"There is no evidence that sleep was universally segmented, and there is also little evidence that segmented sleep is better. A 2021 meta-analysis of studies on biphasic sleep schedules found that segmented-sleeping subjects actually reported “lower sleep quality … and spent more time in lighter stages of sleep.” One reasonable takeaway is that biphasic sleep is like anarchical foraging: Both might have well served some ancient populations some of the time, but neither of them offers a clear solution to modern problems."
ndynan | 4 years ago | on: How to make quitting your addiction easier
The insight is also to use mindfulness to understand the "true" experience of the addictive behavior and come to internalize that it is no longer valuable.
Ezra Klein has a nice interview on the subject: https://podcasts.apple.com/us/podcast/that-anxiety-youre-fee...
ndynan | 4 years ago | on: A New Coefficient of Correlation
There are inherent flaws/assumptions to this approach which Peter Molenaar has done extensive work to critique (See Todd Rose's book on the subject). For anyone who understands the technique presented in this paper, does it also depend on the mean as a model like when calculating Pearson's r?
ndynan | 4 years ago | on: You click a link to a news site, to read an article that seems interesting
ndynan | 4 years ago | on: Novel mind-body program outperforms other treatments for chronic back pain
ndynan | 6 years ago | on: Ask HN: How do I overcome mental laziness?
To build on this thread, I think it's important to feel what is happening when you procrastinate. What is it like in your body when you think about your task. Is it because you think you are going to fail? Because the task involves interpersonal conflict? Is it because you just don't want to do it (not interesting).
If you can start w/ your body + emotions, you'll get a felt sense of what is standing in the way. From there you can start to ask the question "why", is there a reason that those types of emotions happen when faced with this type of task?
As someone with ADHD, anticipatory anxiety has stopped me in my tracks countless times. I try to use this method to be aware there is anxiety, the feelings, and the story I'm telling around that anxiety. For me the anxiety is often a way of not starting, and if I don't start I can't mess up. In recognizing that, I can be a little bit more supportive of myself and be more willing to try.
ndynan | 6 years ago | on: Ask HN: How to Take Good Notes?
http://lsc.cornell.edu/study-skills/cornell-note-taking-syst...
Notes become: - Questions - Notes - Summary
ndynan | 6 years ago | on: Robinhood Is Down Again?
ndynan | 6 years ago | on: The art of interrupting software engineers
As a PM of about 4-years of experience, I understand the author's concerns and at the same time believe that he has solved for the wrong problem; his own anxiety rather than team cohesiveness and trust. The issues he solves for can be solved in different ways without such a negative impact on the team, actually in a very positive manner that increases trust, cohesiveness, and user context.
I'd first like to point out that I've made the mistakes of micromanagement that he mentions in the first section. I also quickly learned how detrimental that behavior is to team relationships, productivity, and outcomes. I'm certainly not perfect!
The way the author solves the problem of pace is by creating regular check-ins every half day. He then goes on to identify, how these check-ins can be used as open to monitor common slow-downs: engineering struggle and product context (he calls is product debt).
I'd first like to make the point that some other engineers have commented here, estimates are estimates, we are agile, you learn things along the way and need to adapt. I believe your job as a PM is not to hold the team to estimates, it is to come up with creative solution and serve as a master facilitator on your team.
So when the author says the following I can't help but notice the irony. I'd explore us all to practice what we preach. Instead care about iterations (sprints) not task micromanagement:
"As a product manager (PM), I often make assumptions as to when a particular user story will be delivered. This is painful because I don’t believe in time estimates and don’t think I should be involved in estimating the relative complexity of a story since I don’t own its implementation.
I know I shouldn’t but I can’t help doing it anyway…"
So how do you solve the problems that the author points to "struggle" and "context" without adding interruptions?
• For struggle, that is what standup is for. Not only standup, but if you create a culture of trust engineers will naturally reach out if they hit road blocks, make a slack channel for your team. It's even better if you can teach your team about red flags, things that the article says which are true to look out for: complexity is rapidly increasing, not feeling confident in the stack/codebase. For any of this to work you MUST create a culture of questions and answers. Yes, all want to look competent, but what's also great is being able to depend on your team.
• Adding to the previous point, this is why small tasks are soo important, [read this book on product flow](https://www.amazon.com/dp/B007TKU0O0/ref=dp-kindle-redirect?...) if complexity is small to begin with you can avoid that issue AND you get the added benefit of smaller iterations, meaning faster red flags. The author points this out too, this is critically important.
• For context, context is king. Want to avoid "Product debt", get your team/tech lead involved from Day 0 of your quarterly/yearly roadmap, they should know everything about the user that the PM does minus the RAW research effort. Run a Kickoff/Inception/IPM that truly integrates your entire team, every engineer should have product context. Devs will then see tricky edge cases, radiate them up to the PM and you can make a call together if the work is necessary.
All of this is to say that there are some good parts of this article, but I think that adding one more check-in is not necessary when there are other ways to solve the problems identified.
ndynan | 7 years ago | on: A guide to difficult conversations
I've found this book very helpful at facilitating communication and it might be of help: https://www.amazon.com/Say-What-You-Mean-Communication/dp/16...
ndynan | 7 years ago | on: Apple’s Shortcuts will flip the switch on Siri’s potential
Interesting to see that the author is a former PR member of http://my.workflow.is/ + has one recent article for TechCrunch.
Oh hey looks they were purchased by Apple: https://techcrunch.com/2017/03/22/apple-has-acquired-workflo...
Quick Edit: I'm not saying that this isn't good technology, rather I'm more concerned that TechCrunch is taking contributors who have ties to products being reported on and may have interests that are not being communicated to readers.