yellow_viper's comments

Interesting, vit D deficiency and TB immunity both run in my family.

The negative effects only happens if incorrectly supplemented.

75% of the population is suboptimal in Magnesium, without Mg - our ability to absorb D diminishes, even with supplementation.

Vitamin D must be supplemented with Vitamin K2 MK7 to ensure the extra calcium generated is deposited in the bones and not in the soft tissues (hypercalcemia)

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/

Magnesium Supplementation in Vitamin D Deficiency. https://www.ncbi.nlm.nih.gov/pubmed/28471760

Low magnesium levels make vitamin D ineffective https://www.sciencedaily.com/releases/2018/02/180226122548.h...

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease https://www.mdpi.com/1422-0067/20/4/896/htm

Vitamin K2: A Vitamin that Works like a Hormone, Impinging on Gene Expression https://www.intechopen.com/books/cell-signalling-thermodynam...

Yep - these conditions are closesly linked

https://scientonline.org/open-access/dystonia-and-its-treatm...

Neurodevelopmental Disorders (Autism, ADHD, Delayed Speech/language, dyspraxia)

>"hyper mobile joints are an uncommon finding in those who do not have attention deficit disorder/attention deficit hyperactivity disorder."

>Differences in the structural integrity of temporal and parietal cortices may underlie wider behavioural phenotypical expression of hypermobility: abnormalities in superior temporal cortex are also seen in autism.11 Inferior parietal cortex can affect proprioceptive awareness and hypermobility is itself linked to dyspraxia.1 Our findings suggest that processes compromising function in neuro-developmental conditions may occur in individuals with hypermobility, putatively enhancing vulnerability to stress and anxiety.

Autism, Joint Hypermobility-Related Disorders and Pain

ASD and HRDs, specially hEDS, are conditions with a strong genetic component, a polymorphic clinical presentation, appearing both in infancy, and sharing several phenotypical features (35). Although existing data does not allow to ascertain increase prevalence of ASD in HRDs, as well as shared underlying patho-mechanisms between both conditions, there is increasing evidence suggesting that these co-occur more often than expected by chance. This requires be confirmed by further investigation which should consider the recent nosological changes both in EDS and the hypermobility spectrum disorders [see (17, 38)], and in ASD (72). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292952

Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry

- In 1988, Hofman et al.[58], in a sample of 30 children with MFS,observed that 17% had attention deficit disorder with or without hyperactivity. A decade later, Harris[59] stated, based on his clinical experience with 200 patients with ADHD, that "hyper mobile joints are an uncommon finding in those who do not have attention deficit disorder/attention deficit hyperactivity disorder."

In Sweden,Hollertz[60,61] also pointed out the frequent co-occurrence of ADHD and JH in adults patients. He observed that an orientation to orthopedic and rehabilitation care was common in these patients due to joint problems. Thus, this author speculates about a possible genetic marker com-mon to ADHD and EDS.

Recently, Koldas Dogan et al.[62]explored JH using the Beighton score in 54 children with ADHD compared to 36healthy controls. In this study, JH was significantly more frequentamong patients than among controls (31.5% vs. 13.9%). In accor-dance with these results,

Shiari et al.[63]also found a higher prev-alence of JH, assessed with the same method of the previous study,among Iranian children with ADHD compared to controls (74.4%vs. 12.8%), confirming an association between ADHD and abnormal collagen conditions.

JOINT HYPERMOBILITY AND AUTONOMIC HYPERACTIVITY: RELEVANCE TO NEURODEVELOPMENTAL DISORDERS

> It is likely that the importance of hypermobility and autonomic dysfunction to the generation and maintenance of psychopathology in neurodevelopmental disorders is poorly appreciated. Work underway(autonomic testing, fMRI) will test the hypothesis that autonomic reactivity and interoceptive sensitivity predispose to the expression of psychiatric symptoms, particularly anxiety

- We demonstrate for the first time that rates of hypermobility and symptoms of autonomic dysfunction are particularly high in adults with neurodevelopmental diagnoses. It is likely that the importance of hypermobility and autonomic dysfunction to the generation and maintenance of psychopathology in neurodevelopmental disorders is poorly appreciated. Work underway(autonomic testing, fMRI) will test the hypothesis that autonomic reactivity and interoceptive sensitivity predispose to the expression of psychiatric symptoms, particularly anxiety. It is further hypothesized that inefficient neural co-ordination of efferent autonomic drive with imprecise interoceptive representations may be amplified in hypermobile individuals. In hypermobility, this mechanism might explain increased vulnerability to stress sensitive and developmental neuropsychiatric conditions. - https://jnnp.bmj.com/content/85/8/e3.40?utm_source=trendmd&u...

[Searching for a biological marker common for both ADHD and EDS].

- https://www.ncbi.nlm.nih.gov/pubmed/22468413 - speculated about a common biological base shared by ADHD and EDS after observing the frequent cooccurrence of both pathologies in a clinical setting.

Connective tissue problems and attention deficit and hyperactivity

Attachments - [ADHDBaeza-Velascoetal.2015.pdf](https://checkvist-prod-uploads.s3.amazonaws.com/u/OKFCuEQ7Zl...)

- To the Editor, The heritable disorders of the connective tissue are a group of genetic disorders affecting connective tissue matrix proteins that classically include Marfan syndrome (MFS), Ehlers–Danlos Syndrome (EDS), benign joint hypermobility syndrome and osteogenesis imperfecta (Grahame 2000). As connective tissue is found throughout the body, the clinical manifestations of these disorders are varied, including disturbances in different systems (skeletal, ocular, cardiovascular, etc.). A common feature of the heritable disorders of the connective tissue is joint hypermobility (JH), which is a highly heritable condition characterized by an increased range of motion of the joints as a consequence of connective tissue involvement.We encountered a 7-year-old boy addressed by teachers due to school problems. His mother suffer from MFS such as his maternal grandmother who died by cardiac complications. Considering familial antecedents, his morphotype (long bone overgrowth), JH and ocular ...

A connective tissue disorder may underlie ESSENCE problems in childhood

Attachments - [1-s2.0-S0891422216302402-main.pdf](https://checkvist-prod-uploads.s3.amazonaws.com/u/aghis3LMNv...)

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Attachments - [Screenshot_2019-06-27_at_16.53.23.png](https://checkvist-prod-uploads.s3.amazonaws.com/u/dm7JuPP8Gq...)

Attention-deficit/hyperactivity disorder, joint hypermobility-related disorders and pain: expanding body-mind connections to the developmental age.

>Recent research seems to indicate a degree of co-occurrence of JHS/hEDS and some neuro-developmental disorders including attention-deficit/hyperactivity disorders (ADHD) and developmental coordination disorder (DCD). In the area of ADHD, researchers found that adults with ADHD had higher rates of JH and problems with automatic control of body functions (dysautonomia) compared to healthy controls. Other researchers observed high co-occurrence of JH or EDS with ADHD. Concerning DCD, children with DCD have more symptoms associated with JHS/hEDS compared to typically developing children. The relationship between JH and DCD may be due to poor positional sensing in affected children.

- https://www.ncbi.nlm.nih.gov/pubmed/29446032

A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility

- This research supports a growing body of literature indicating that immune-mediated disorders are a common comorbid feature in hEDS and GJH. In addition, we have also shown that this dysfunction may be paired with endocrine dysregulation, leading to complex immune and hormonal exophenotypes, such as autoimmune disorders, allergic rhinitis, asthma, endometriosis, and dysmenorrhea. While we have not addressed autism and GJH comorbidity rates in this study, their co-occurrence in the adult ASD female population suggests links between the dysfunction of connective tissue and the immune and endocrine systems in this subpopulation. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867488/

Rationale for Dietary Antioxidant Treatment of ADHD [[MDPI - 2018](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946190/)]

>ADHD might thus be a (non) allergic hypersensitivity disorder caused by an environmental trigger, based on a non-IgE dependent histamine release from mast cells and basophilic granulocytes, since the histamine H3 receptor is involved in hyperactivity and promotes dopamine release in the frontal cortex. Moreover, polymorphisms in the histamine N-methyl transferase (HNMT) gene, impairing histamine clearance, were found to affect the behavioral responses to food additives, which increase histamine levels #ADHD

>If you go low fat, you necessarily go low protein too, so you need to replace that with carbohydrates. Even more, you now need "fortified" carbohydrates to get the needed B vitamins and other nutrients usually found in fatty foods, and those will be refined carbohydrates; which is what the American Health Association now recommends. Yes, they actually recommend that people should eat enriched cereals and other bullshit like that.

'B vitamins' is very vague. Are you talking about B12? If so, farm animals are supplemented with that anyway - so it's just supplements with more steps. Also, once you hit 40-60 most people have problems absorbing enough B12 and should be supplementing regardless of what they eat.

>A high carbs diet made of "healthy, complex carbs" is a myth ;-)

Hmm, how so? The benefits of HCLF are well documented

Benefits of HCLF:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691673/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967195/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073139/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245565/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583329/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844163/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677007/

Low Carbohydrate Diets and mortality:

http://www.ncbi.nlm.nih.gov/pubmed/20820038

>Now tell me, how does that help in establishing why the plane actually crashed and what to do to solve it? That's how "calorie restriction" sounds as an explanation, being a prima facie observation. Of course you're reducing calories. But HOW you're reducing those calories makes all the difference.

A ketogenic diet can also reduce hyperglycemia in diabetes, but it is not the wisest choice for the long term, diabetes or not. Addressing the cause of the disease, excess unhealthy fats in the case of diabetes, is better than merely treating the symptoms (hyperglycemia), especially if you can do both with the same intervention (http://www.pcrm.org/health/diabetes-resources).

>Here's one of the largest studies on dietary fat, done on 50,000 women, spanning for 8 years, showing that going low fat did absolutely nothing to prevent heart disease: https://www.ncbi.nlm.nih.gov/pubmed/28515068

Whole-food plant-based diets are the only diets shown to reverse heart disease in a clinical setting:

Dr. Richard Fleming showing progression with low-carb diet and reversal with WFPB https://www.ncbi.nlm.nih.gov/pubmed/1110832

Dr. Dean Ornish reversing heart disease with a WFPB diet https://www.ncbi.nlm.nih.gov/pubmed/9863851

Dr. Caldwell Esselstyn Jr reversing heart disease with a WFPB diet https://www.ncbi.nlm.nih.gov/pubmed/25198208

http://www.ncbi.nlm.nih.gov/pubmed/17518696 CONCLUSIONS: Long-term consumption of a low-calorie low-protein vegan diet or regular endurance exercise training is associated with low cardiometabolic risk. Moreover, our data suggest that specific components of a low-calorie low-protein vegan diet provide additional beneficial effects on blood pressure.

http://www.ncbi.nlm.nih.gov/pubmed/7019459 The study suggests an adverse effect of consumption of beef on plasma lipid and BP levels.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312295/

http://www.ncbi.nlm.nih.gov/pubmed/15172426 Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl

Dr. Kim Williams - the President of American College of Cardiology said, "There are two types of cardiologists: vegans and those who haven't read the data."

https://nutritionfacts.org/video/low-carb-diets-and-coronary...

https://nutritionfacts.org/video/how-not-to-die-from-heart-d...

https://nutritionfacts.org/video/the-problem-with-the-paleo-...

>I also wish people would stop posting YouTube videos btw. I don't watch YouTube bullshit. Post links to studies that I can verify.

Wasn't linking a youtube video. He puts a video on the page to make it easy to digest but all the sources are cited.

https://nutritionfacts.org/video/what-causes-insulin-resista...

--

You've picked the most obvious one. Heart disease and animal produce link is well established and accepted.

Fat 100% causes diabetes. So does low-fibre or high-sugar though (https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072693/). There is also a lot of extremely shady shit going on in diabetes research like this >>

“This study was supported by grants from the American Diabetes Association, the Minnesota Beef Council, and the Colorado and Nebraska Beef Councils”.

Cancer is established but the risk isn't that great (still causes 21% of bowel cancers though)

What is N.B fasting?

I do 16/8 I.F fasting on a HCLF diet and have never experienced any of those issues.

There is plenty of evidence showing the benefits of ketosis on the body, and benefits from people switching from SAD to Keto reversing diabetes and the likes - but that's more down to calorie restriction. With regular keto you're raising your risk long-term for diabetes, heart-disease, cancer and stroke due to increased meat/dairy/egg consumption.

https://nutritionfacts.org/video/what-causes-insulin-resista...

You're far better just eating a varied diet with as little animal produce as possible and doing I.F which releases 5x the amount of ketones than the keto diet.

I believe Tesla rolled out an update shortly after the crash that fixed the 'bug' of it not recognising the white trailer against the blue sky.

They're doing this because people were calling on tougher penalties and an independent watchdog for social media. They don't want oversight so they pay extra for moderation.

People won't buy self-driving cars (well some will, but not the majority). These cars will be running 24/7 in a ride-sharing service.

How does it increase the legitimacy? Page likes aren't public (when viewing from/as the page).

Doesn't really matter if it's better. TVs still use HDMI and most likely will for another 10+ yr. They're just reducing the functionality of the laptop.

Depends on your use. The only ports I don't use on my mac are the Mini dvi. I use both USBs daily, HDMI when at friends, and the SD card slot for loading pictures from clients - and don't want to carry adapters around with me. The loss of MagSafe is another big one.

Kinda defeats the purpose having a nice sleek macbook only having to plug something like this into it

http://cdn.bgr.com/2016/12/macbook-pro-2016-hyperdrive-all-i...

Been using Apple since I was 10 (First computer was a PowerPC). Have owned most iPhones and all around been an Apple fanboy.

The latest macbook was the last straw, a 40% increase in price is not acceptable. I switched to a Nexus (and loving it). I bought a macbook for Uni (2015 model - The loss of ports and addition of a battery draining touchbar doesn't appeal) but only due to the fact that I needed something that would perform well and last all day. (Gaming laptops only last 2-5hrs).

Unless they unveil some version with ports reinstated and a huge battery (16+ hrs) I don't see myself ever going back.

>They usually say at least three hours study for each hour of class, I used that as my guide

That would put me at 18hrs of studying a day :/

Due to years of posting nonsense online, English is easy for me (top of the class). Not looking forward to my 2 science requirements though as thats where I struggle to concentrate.

What's with all the comics?

For anyone who's completed a CS degree, how much studying did you do per night. I understand working on projects etc can eat up hours but I don't really include that.

Back at college just now and starting university in Sept. I had never studied in my life until college (coasted of natural ability all my life) and I'm finding it difficult to even spend 1hr a night. (Average mark currently is 80%) 5hrs per night seems insane to me.

When studying I either understand the concept fully and fire through it rapid. Don't understand it and spend ages figuring it out/trying to find answers online. Or have no idea, can't find anything in the textbooks/online and resort to crying in the corner.

wouldn't tolerance make it pointless to do this everyday also? Seems once every 3 days would be more beneficial.

35/mo is pricey but nothing compared to cable prices.

I will be interested to see what channels this will offer in the UK. If it offers all existing freeview channels + some premium ones I can see a lot of people cutting the cord.

Set my VPN to LA but still can't get in even in incognito. Not sure how it's determining location. As I have other location tracking blocked.

edit: got it working with this https://chrome.google.com/webstore/detail/manual-geolocation...

1 in 30 pound coins is fake. If you have a handful of smash and examine the pound coins you can usually find at least 1 fake one. Counterfeiters made millions before anyone caught on

Because we've accepted it. We know the government is watching us 24/7 and no one cares. This is the new norm.

Stories like this fill me with a slight bit of hope that encryption works

Voats model is good but filled with angry men (and the people on fatpeoplehate seem to be mainly women from what I've read). We need a max exodus from Reddit to even the odds