zaking17's comments

Would anyone knowledgeable about the field update their priors about whether we’ll see commercial fusion in the next 30 years, after seeing these results? If not, is there a big milestone we’re waiting for? Or will fusion advancement be a slow grind with many small improvements over decades?

Delfina [https://delfina.com/] | Software engineer (junior or senior, back or front or fullstack) | Full time | Remote (Anywhere)

We are building intelligent pregnancy care for healthier moms and babies. Our motivating challenge is the fact that in the United States, healthcare outcomes for pregnancy are significantly worse than in other similarly developed countries. We believe our technology-enabled solutions will help doctors better scale to better use data and in the end, deliver better care to their patients. We are looking for people who believe in our mission to join our team!

We are looking for both junior and senior level software engineers. And we’re open to backend, frontend, or fullstack positions. It will help if you experience in one or more of:

- Flutter for iOS and Android or React - Python (FastAPI) - PostreSQL, GraphQL - GCP, GitHub Actions

Experience in healthtech, pregnancy care, machine learning, cloud operations, and design are all valuable as well!

Delfina offers competitive benefits, including health, dental, and vision coverage, unlimited PTO, and 10 weeks fully paid leave for parents of all genders and any parental event including adoption.

https://delfina.com/careers.html

On the function hooks, that would be awesome. I was just implementing some of those SQL commands.

And I will look more at the realtime libraries to see the new stuff. Thanks for all the open code!!

I love the direction Supabase is taking; finding the building blocks of modern applications (database, auth, functions, presence, realtime subscriptions), making them easy to use, and then sharing the source code. I’ve learned a ton just from cruising around supabase GitHub.

Can you say which of these new components will be open sourced? There are some other features (e.g. function hooks) that are also closed-source at the moment. Is Supabase heading for an “open core” model?

These are evocative images. I love a bunch of them! Knowing that this model was trained on a huge corpus of existing images makes them feel a bit like the output of a visual search engine -- finding relevant pieces and stitching them together. But it's more than that, because the stitching happens at different levels. They are often thematically and aesthetically cohesive in a way that feels intelligent.

Maybe we're just search engines of a similar kind.

An additional aspect of human art is that it (usually) takes time to make. The artist might spend many hours creating and reflecting and creating some more. The artist's engagement with the work makes its way into the final product, and that makes human art richer. Could future Dall-E version create sketches and iterations of a work; is there a limit to this mimicry?

I'm feeling future shock; heavy future shock.

Amyris | Roles in Data Engineering, DevOps, IT | Remote | Amyris has developed an industry-leading platform for designing and building synthetic organisms. Our technology is being used today to make clean beauty products, bio-based renewable chemicals, and even vaccine ingredients. We are engineers to support these data and software driven technologies.

* Associate Director, Data Engineering: https://jobs.lever.co/amyris/b7e79c31-b511-485b-a82c-08566ef...

* Senior Cloud DevOps Engineer: https://jobs.lever.co/amyris/d3946885-6e0e-4eae-9425-62e96c2...

* Senior Network Engineer: https://jobs.lever.co/amyris/2b477145-d3a5-4d2a-a6fe-1e1c284...

* Associate Director, IT Operations: https://jobs.lever.co/amyris/8344de25-5b44-4d33-a661-2edf752...

Come work with us at the cutting edge of synthetic biology!

See all at https://amyris.com/careers-north-america

Reach out to me: [email protected] if you're interested or have questions.

Amyris (https://amyris.com/careers-north-america) | Engineers, Designers, Interns | Emeryville, CA | Full time | ONSITE or REMOTE

Amyris has developed a platform for designing and building synthetic organisms. Our technology is being used today to make clean beauty products, bio-based renewable chemicals, and even vaccine ingredients.

Among the tools we have developed are a CAD/CAM system for genetic engineering: a compiler toolchain whose target architecture is life itself. This stack physically integrates high level genetic modules into microbial hosts. We also derive novel strains through random mutagenesis and directed evolution. Using our custom control platform, we then subject these experimental organisms to high throughput performance screening in our state-of-the-art robot labs.

Specifically, we are looking for a senior software engineer to join our software engineering team in R&D https://jobs.lever.co/amyris/475990a5-d88d-464b-8444-62ce51c...

We are also opening a DevOps position and other tech positions in the next couple week. If you're interested, you can reach out to me at [email protected]

You might also want some pathways to be pre-validated to work together in certain cellular contexts, like they have been doing with the BioBricks project

agreed! a couple things seem to be holding this back:

- the academic publishing model incentivizes groups to build their own tools

- the small-ish market for something like this has kept commercial software from taking off (Genomatica started by building a tool like this in the early 2000s, before pivoting to bioprocess development)

- it's really hard to specify pathways in concrete physical terms. Even a chemical like glucose is actually a collection of pseudo-isomers (alpha & beta D-glucose). And try firmly defining a "gene" in your database!

that being said, there's a ton of work going on in this field and many cool projects to follow: https://dd-decaf.eu, https://biocyc.org, http://bigg.ucsd.edu, http://metanetx.org

It’s cool to see this on HN. It’s a common activity in metabolic modeling & metabolic engineering circles to build new pathway visualization tools (I spent a chunk of my PhD on one called “Escher”). I keep waiting for a tool to come along that’s good enough to be sticky and win this little market. But it might be more like IDEs, where there are some classics (pathway tools = emacs?), and an endless supply of new entrants.

I saw Terry Sejnowski give a talk last week in San Diego, and he made the exact same suggestion. He did not provide any evidence, but it's hard not to take his ideas seriously.

Bioengineering. I'll DM you on Twitter :)

[EDIT] Didn't work. Feel free to email me. Address is in my Bio.

It's fun to see San Diego at the top of HN.

I'm finishing a PhD at UC San Diego, and I've noticed a few things. First, there is a different dynamic for biotech talent. The biotech scene in SD is strong, and people seem drawn to that. Second, in contrast to LA at least, commuting in SD is not terribly difficult. And there is a light rail (trolley) beginning construction up to the UCSD campus from downtown. Third, this city is a draw for people (like me) who are looking for something less bustling than SF or LA, and I think it's important to try to keep young talent here by selling this idea. In biotech, we desperately need better software engineers.

SVG Crowbar might be useful for pulling out the SVG images (unfortunately it's for Chrome only):

http://nytimes.github.io/svg-crowbar/

Author here. This is a grad school project built with D3. You can also see it embedded in our model database http://bigg.ucsd.edu.

I was looking for a less-complicated alternative to nxhtml/mumamo and html5.el (which requires xhtml syntax). I've played with web-mode for a few minutes, and it seems great. Handles html, css, js nicely.

Only concern so far: javascript variables with underscores do not highlight correctly.

Yes, I use Everpix and I've been really happy with it. However, I like the photo upload tools that come with Dropbox, so now I collect, sort, and edit photos in Dropbox, then I transfer them to a static(ish) Everpix library that distributes them back to my iPhone/iPad/browser. Seems kind of circular, but it works really well. And I have 170,000 photos in the cloud for less than the cost of a Dropbox upgrade.