bsmrea's comments

bsmrea | 8 years ago | on: No human genome has ever been completely sequenced

This is a nice analogy to genome assembly and there are some technologies that try to label DNA before sequencing to aid reconstruction. The one that comes to mind when reading your post is the 10X Genomics system, which acts as a preprocessor before Illumina sequencing. The idea is that you can introduce nucleotide tags into the DNA molecule(s) before sequencing, then use the tags to figure out what short reads came from the same DNA fragment later on. There is a nice video on 10X's website explaining how this works and how it helps:

https://www.10xgenomics.com/technology/

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