dashmeet's comments

dashmeet | 7 months ago | on: On doing hard things

> But I think there’s a quiet dignity in the almost [success] stories too.

The last line hit hard. Need to remind myself of this sometimes

dashmeet | 2 years ago | on: OpenAI Deal Lets Employees Sell Shares at $86B Valuation

I’m pretty sure you’re looking at trailing PE. If you look at forward PE it’s only about 35. If you tripled profit, we’d be looking at about 12.

Using trailing PE shows an inaccurate picture for a high growth company so it makes more sense to just take the last quarter and project forwards.

dashmeet | 2 years ago | on: Malignant melanoma deploys elegant molecular mechanism to evade immune responses

They do have adaptive pressure. 100s of millions of years of single cell evolutionary instincts live within our cells and the desire to survive. Being a multicellular organism is a relatively new learned behavior, and a human cell returning to that old mindset is basically cancer.

The only problem is that these individually minded (cancer) cells have every ability of your healthy cells and have basically stopped caring about the greater whole and care about themselves. Then they evolve at a micro level for their survival to fend off chemo, immune system, radiation etc. All it takes is one adapted/surviving cell to come back strong.

The sophisticated mechanisms for evasion exist because they have all the methods of evading your immune system that healthy multicellular organisms need to function and they multiply and increase their mutation rate to try new methods to survive and thrive.

I view cancer cells as single cells to understand their behavior with the adaptations of all the healthy cells returning to their “baser instincts”.

Source: Caretaker of a cancer patient and former cell bio major

PS: Take all the above with a grain of salt

Fuck Cancer

dashmeet | 2 years ago | on: Exciting SQLite Improvements Since 2020

I wonder how this compares to using redis for key value caching purposes?

Definitely reduces the need for another dependency if that’s your thing and it fits your needs

dashmeet | 3 years ago | on: Association between influenza vaccination and risk of stroke in Alberta, Canada

Another variable that causes issues in the results is the effectiveness of the vaccine and the evolution of the virus over years with retained immunity.

For example:

A flu shot from years ago can protect against a flu from this year or in the future. So even if the flu vaccine isn’t effective in its current year, the immunity lasts for many years to those antigens. The strain of flu that’s currently dominant can fluctuate to newer or older variants. Controlling for this is even more confusing

A guess this year could help in future years

dashmeet | 3 years ago | on: Why is inflammation a dangerous necessity?

Sounds like exercise or maybe a dry sauna would be a cost effective non pharmaceutical way, short term increase in inflammation that results in a long term decrease in inflammation. Same thing with injuries and fractures but that’s more unrelated.
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